DMBX1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DMBX1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DMBX1 at tissue level.

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0008344Biological processadult locomotory behavior
GO_0008343Biological processadult feeding behavior
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007417Biological processcentral nervous system development
GO_0007420Biological processbrain development
GO_0048589Biological processdevelopmental growth
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity

IV. Literature review

[source]
Gene nameDMBX1
Protein nameDiencephalon/mesencephalon homeobox protein 1 (Orthodenticle homolog 3) (Paired-like homeobox protein DMBX1)
SynonymsPAXB
OTX3
MBX
DescriptionFUNCTION: Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity). .

AccessionsQ8NFW5
ENST00000360032.4 [Q8NFW5-2]