SP3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	16 studies	26% ± 10%	Explore
natural killer cell	11 studies	21% ± 4%	Explore
macrophage	11 studies	33% ± 13%	Explore
pericyte	11 studies	21% ± 5%	Explore
fibroblast	11 studies	23% ± 6%	Explore
microglial cell	10 studies	29% ± 11%	Explore
B cell	9 studies	22% ± 5%	Explore
classical monocyte	9 studies	25% ± 9%	Explore
epithelial cell	8 studies	33% ± 14%	Explore
oligodendrocyte precursor cell	8 studies	27% ± 13%	Explore
naive B cell	7 studies	18% ± 2%	Explore
non-classical monocyte	7 studies	30% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	20% ± 3%	Explore
CD4-positive, alpha-beta T cell	7 studies	20% ± 5%	Explore
plasmacytoid dendritic cell	7 studies	21% ± 4%	Explore
dendritic cell	7 studies	27% ± 15%	Explore
oligodendrocyte	7 studies	26% ± 7%	Explore
monocyte	7 studies	26% ± 8%	Explore
T cell	6 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	22% ± 4%	Explore
CD8-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
interneuron	6 studies	31% ± 17%	Explore
myeloid cell	6 studies	26% ± 6%	Explore
basal cell	6 studies	29% ± 14%	Explore
astrocyte	6 studies	32% ± 9%	Explore
leukocyte	5 studies	21% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	19% ± 4%	Explore
mucosal invariant T cell	5 studies	19% ± 2%	Explore
adipocyte	5 studies	24% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	20% ± 2%	Explore
endothelial cell of lymphatic vessel	5 studies	23% ± 5%	Explore
GABAergic neuron	5 studies	40% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	18% ± 3%	Explore
mature NK T cell	4 studies	19% ± 4%	Explore
plasma cell	4 studies	34% ± 7%	Explore
ciliated cell	4 studies	27% ± 2%	Explore
lymphocyte	4 studies	28% ± 7%	Explore
hepatocyte	4 studies	32% ± 13%	Explore
glutamatergic neuron	4 studies	51% ± 16%	Explore
smooth muscle cell	4 studies	22% ± 3%	Explore
gamma-delta T cell	4 studies	26% ± 9%	Explore
neuron	4 studies	38% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	18% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	21% ± 3%	Explore
plasmablast	3 studies	29% ± 8%	Explore
mast cell	3 studies	22% ± 5%	Explore
mononuclear phagocyte	3 studies	24% ± 6%	Explore
neural progenitor cell	3 studies	23% ± 1%	Explore
connective tissue cell	3 studies	20% ± 4%	Explore
myofibroblast cell	3 studies	21% ± 6%	Explore
alveolar macrophage	3 studies	28% ± 12%	Explore
regulatory T cell	3 studies	20% ± 1%	Explore
goblet cell	3 studies	29% ± 15%	Explore
transit amplifying cell	3 studies	34% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	32% ± 16%	Explore
peripheral blood	6 studies	24% ± 6%	Explore
lung	5 studies	25% ± 5%	Explore
eye	3 studies	23% ± 9%	Explore
liver	3 studies	36% ± 14%	Explore
adipose	3 studies	28% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3772.58	1445 / 1445	100%	26.51	183 / 183
ovary	100%	4664.44	180 / 180	100%	16.22	429 / 430
lung	100%	5019.97	577 / 578	100%	21.95	1154 / 1155
breast	100%	6274.39	459 / 459	99%	27.47	1112 / 1118
thymus	100%	5630.13	653 / 653	99%	19.52	598 / 605
brain	99%	2196.49	2615 / 2642	100%	17.23	704 / 705
intestine	100%	4276.13	966 / 966	99%	17.44	520 / 527
uterus	100%	6040.04	170 / 170	98%	21.13	451 / 459
stomach	100%	2858.23	359 / 359	98%	17.92	281 / 286
bladder	100%	4953.38	21 / 21	98%	15.60	494 / 504
pancreas	99%	2023.55	326 / 328	98%	16.63	175 / 178
prostate	100%	4165.90	245 / 245	97%	16.41	489 / 502
skin	100%	5380.21	1809 / 1809	94%	16.26	442 / 472
kidney	100%	2709.36	89 / 89	94%	15.25	843 / 901
adrenal gland	100%	2635.34	258 / 258	89%	10.01	204 / 230
liver	100%	2362.72	226 / 226	82%	8.51	332 / 406
adipose	100%	6458.52	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5311.63	1335 / 1335	0%	0	0 / 0
spleen	100%	4565.78	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	22.78	45 / 45
ureter	0%	0	0 / 0	100%	5.00	1 / 1
muscle	100%	2833.82	802 / 803	0%	0	0 / 0
heart	98%	2170.76	844 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	13.75	28 / 29
peripheral blood	95%	4206.12	878 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	71%	7.64	57 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060136	Biological process	embryonic process involved in female pregnancy
GO_0030324	Biological process	lung development
GO_0048596	Biological process	embryonic camera-type eye morphogenesis
GO_0001779	Biological process	natural killer cell differentiation
GO_0001892	Biological process	embryonic placenta development
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0001829	Biological process	trophectodermal cell differentiation
GO_0001889	Biological process	liver development
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0030217	Biological process	T cell differentiation
GO_0030851	Biological process	granulocyte differentiation
GO_0060216	Biological process	definitive hemopoiesis
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0048706	Biological process	embryonic skeletal system development
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0043353	Biological process	enucleate erythrocyte differentiation
GO_0001503	Biological process	ossification
GO_0002318	Biological process	myeloid progenitor cell differentiation
GO_0030219	Biological process	megakaryocyte differentiation
GO_0030224	Biological process	monocyte differentiation
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0030183	Biological process	B cell differentiation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0032993	Cellular component	protein-DNA complex
GO_0005654	Cellular component	nucleoplasm
GO_0017053	Cellular component	transcription repressor complex
GO_0005829	Cellular component	cytosol
GO_0016605	Cellular component	PML body
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977	Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682	Molecular function	chromatin binding
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SP3
Protein name	Sp3 transcription factor Specificity protein 3 internally initiated isoform 1 Transcription factor Sp3 SP3 protein Specificity protein 3 internally initiated isoform 2 Transcription factor Sp3 (SPR-2) Transcription factor SP3
Synonyms
Description	FUNCTION: Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. .
Accessions	ENST00000418194.7 [Q02447-5] H0Y7L6 Q02447 ENST00000651846.1 B7ZLN9 A0A494C070 Q86TP0 A0A494C1G8 ENST00000418194 ENST00000416195.1 A0A494C0Z6 Q8WWU2 Q8WWU3 ENST00000310015.12 [Q02447-1] ENST00000652005.2 ENST00000650743.1 H0Y6K5 Q8TE45

SP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review