ZBED6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZBED6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZBED6 at tissue level.

III. Associated gene sets

GO_0051148Biological processnegative regulation of muscle cell differentiation
GO_0061178Biological processregulation of insulin secretion involved in cellular response to glucose stimulus
GO_0001835Biological processblastocyst hatching
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0034451Cellular componentcentriolar satellite
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0046983Molecular functionprotein dimerization activity
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZBED6
Protein nameZinc finger BED domain-containing protein 6
Synonyms
DescriptionFUNCTION: Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (By similarity). Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (By similarity). Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (By similarity). Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (By similarity). Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (By similarity). Positively regulates the cell cycle and survival of pancreatic beta cells . Binds to the CDH2 gene and may directly repress CDH2 transcription (By similarity). Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (By similarity). May also play a role in embryonic beta cell differentiation (By similarity). May play a role in insulin sensitivity and glucose clearance (By similarity). .

AccessionsENST00000550078.3
P86452