PRDM5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0000278Biological processmitotic cell cycle
GO_0032259Biological processmethylation
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1903053Biological processregulation of extracellular matrix organization
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0008168Molecular functionmethyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRDM5
Protein namePR/SET domain 5
PR domain zinc finger protein 5 (EC 2.1.1.-) (PR domain-containing protein 5)
Alternative protein PRDM5
SynonymsPFM2
DescriptionFUNCTION: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells. .

AccessionsH0Y9S1
ENST00000394435.2 [Q9NQX1-3]
ENST00000515109.5 [Q9NQX1-4]
ENST00000502409.1
L0R6M5
ENST00000428209.6 [Q9NQX1-2]
Q9NQX1
ENST00000264808.8 [Q9NQX1-1]