Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 11 studies | 23% ± 8% | |
| endothelial cell of artery | 11 studies | 48% ± 11% | |
| capillary endothelial cell | 4 studies | 17% ± 1% | |
| basal cell | 3 studies | 18% ± 1% | |
| endothelial cell of vascular tree | 3 studies | 20% ± 4% |
Insufficient scRNA-seq data for expression of HEY1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 2304.17 | 2640 / 2642 | 100% | 122.68 | 702 / 705 |
| lung | 99% | 1744.64 | 573 / 578 | 61% | 21.00 | 708 / 1155 |
| breast | 100% | 2092.71 | 459 / 459 | 48% | 5.89 | 532 / 1118 |
| thymus | 98% | 768.31 | 639 / 653 | 42% | 6.51 | 256 / 605 |
| skin | 53% | 280.92 | 955 / 1809 | 85% | 34.08 | 403 / 472 |
| bladder | 90% | 1059.67 | 19 / 21 | 31% | 7.22 | 154 / 504 |
| uterus | 66% | 368.14 | 113 / 170 | 45% | 10.87 | 205 / 459 |
| esophagus | 73% | 456.58 | 1062 / 1445 | 37% | 9.79 | 67 / 183 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.83 | 1 / 1 |
| adipose | 100% | 2279.80 | 1201 / 1204 | 0% | 0 | 0 / 0 |
| heart | 100% | 1386.78 | 857 / 861 | 0% | 0 | 0 / 0 |
| muscle | 99% | 1204.84 | 793 / 803 | 0% | 0 | 0 / 0 |
| intestine | 91% | 653.32 | 876 / 966 | 6% | 0.66 | 33 / 527 |
| prostate | 89% | 691.38 | 219 / 245 | 5% | 0.39 | 24 / 502 |
| kidney | 29% | 112.66 | 26 / 89 | 57% | 8.97 | 511 / 901 |
| stomach | 70% | 370.61 | 253 / 359 | 10% | 1.02 | 28 / 286 |
| blood vessel | 74% | 488.78 | 985 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 12% | 53.50 | 32 / 258 | 58% | 9.50 | 134 / 230 |
| pancreas | 20% | 69.90 | 66 / 328 | 33% | 3.01 | 59 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 51% | 8.60 | 23 / 45 |
| spleen | 43% | 159.04 | 103 / 241 | 0% | 0 | 0 / 0 |
| ovary | 24% | 111.36 | 43 / 180 | 7% | 1.24 | 31 / 430 |
| liver | 13% | 74.12 | 29 / 226 | 13% | 1.53 | 51 / 406 |
| eye | 0% | 0 | 0 / 0 | 19% | 2.19 | 15 / 80 |
| peripheral blood | 16% | 230.41 | 147 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.51 | 2 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0003161 | Biological process | cardiac conduction system development |
| GO_0003190 | Biological process | atrioventricular valve formation |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0060347 | Biological process | heart trabecula formation |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0060411 | Biological process | cardiac septum morphogenesis |
| GO_0003180 | Biological process | aortic valve morphogenesis |
| GO_0003203 | Biological process | endocardial cushion morphogenesis |
| GO_0072359 | Biological process | circulatory system development |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0051151 | Biological process | negative regulation of smooth muscle cell differentiation |
| GO_0060317 | Biological process | cardiac epithelial to mesenchymal transition |
| GO_0003208 | Biological process | cardiac ventricle morphogenesis |
| GO_2001212 | Biological process | regulation of vasculogenesis |
| GO_0070168 | Biological process | negative regulation of biomineral tissue development |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0035912 | Biological process | dorsal aorta morphogenesis |
| GO_0060716 | Biological process | labyrinthine layer blood vessel development |
| GO_0060412 | Biological process | ventricular septum morphogenesis |
| GO_0009952 | Biological process | anterior/posterior pattern specification |
| GO_0060842 | Biological process | arterial endothelial cell differentiation |
| GO_0003184 | Biological process | pulmonary valve morphogenesis |
| GO_0050767 | Biological process | regulation of neurogenesis |
| GO_0036304 | Biological process | umbilical cord morphogenesis |
| GO_0045746 | Biological process | negative regulation of Notch signaling pathway |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000987 | Molecular function | cis-regulatory region sequence-specific DNA binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0046983 | Molecular function | protein dimerization activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | HEY1 |
| Protein name | Hes related family bHLH transcription factor with YRPW motif 1 Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1) Hairy/enhancer-of-split related with YRPW motif protein 1 |
| Synonyms | HESR1 CHF2 HERP2 HRT1 BHLHB31 |
| Description | FUNCTION: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' . Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 . Involved in the regulation of liver cancer cells self-renewal . . |
| Accessions | ENST00000674295.1 A0A6I8PRS3 ENST00000674160.1 ENST00000674177.1 ENST00000337919.9 [Q9Y5J3-2] E5RHK6 ENST00000674418.1 ENST00000354724.8 [Q9Y5J3-1] Q9Y5J3 A0A6I8PRC2 ENST00000518733.1 A0A6I8PU82 ENST00000674358.1 A0A6I8PIY0 |
