TCF23 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TCF23 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TCF23 at tissue level.

III. Associated gene sets

GO_0010628Biological processpositive regulation of gene expression
GO_0051148Biological processnegative regulation of muscle cell differentiation
GO_0030154Biological processcell differentiation
GO_0046697Biological processdecidualization
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032502Biological processdevelopmental process
GO_0007517Biological processmuscle organ development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000791Cellular componenteuchromatin
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0046983Molecular functionprotein dimerization activity
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameTCF23
Protein nameTranscription factor 23 (TCF-23) (Class A basic helix-loop-helix protein 24) (bHLHa24)
SynonymsBHLHA24
DescriptionFUNCTION: Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity). .

AccessionsENST00000296096.6
Q7RTU1