NPAS1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NPAS1 at tissue level.

III. Associated gene sets

GO_0001964Biological processstartle response
GO_0042711Biological processmaternal behavior
GO_0007417Biological processcentral nervous system development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding

IV. Literature review

[source]
Gene nameNPAS1
Protein nameNeuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5)
Neuronal PAS domain protein 1
SynonymsMOP5
PASD5
BHLHE11
DescriptionFUNCTION: May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity). Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity). .

AccessionsM0QX32
Q99742
M0R2M8
ENST00000594257.1
ENST00000602212.6 [Q99742-1]
ENST00000449844.6 [Q99742-1]
ENST00000439365.6 [Q99742-2]
ENST00000594670.1
ENST00000602189.5
M0R1R8