ARID4B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	46 studies	41% ± 15%	Explore
B cell	40 studies	36% ± 12%	Explore
natural killer cell	38 studies	38% ± 12%	Explore
fibroblast	37 studies	33% ± 12%	Explore
pericyte	34 studies	32% ± 12%	Explore
T cell	33 studies	35% ± 11%	Explore
CD8-positive, alpha-beta T cell	33 studies	35% ± 11%	Explore
smooth muscle cell	29 studies	29% ± 9%	Explore
CD4-positive, alpha-beta T cell	29 studies	37% ± 12%	Explore
regulatory T cell	28 studies	40% ± 12%	Explore
macrophage	27 studies	32% ± 16%	Explore
mast cell	22 studies	31% ± 11%	Explore
mature NK T cell	20 studies	35% ± 9%	Explore
memory B cell	20 studies	35% ± 7%	Explore
naive B cell	20 studies	35% ± 9%	Explore
astrocyte	20 studies	42% ± 18%	Explore
classical monocyte	19 studies	26% ± 11%	Explore
endothelial cell of lymphatic vessel	18 studies	37% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	35% ± 12%	Explore
plasmacytoid dendritic cell	18 studies	32% ± 10%	Explore
non-classical monocyte	18 studies	28% ± 14%	Explore
oligodendrocyte precursor cell	17 studies	42% ± 18%	Explore
monocyte	16 studies	31% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	41% ± 12%	Explore
ciliated cell	16 studies	33% ± 14%	Explore
oligodendrocyte	16 studies	54% ± 15%	Explore
gamma-delta T cell	16 studies	43% ± 13%	Explore
microglial cell	16 studies	45% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	41% ± 11%	Explore
basal cell	15 studies	35% ± 17%	Explore
conventional dendritic cell	15 studies	27% ± 16%	Explore
capillary endothelial cell	15 studies	29% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	33% ± 11%	Explore
mucosal invariant T cell	14 studies	37% ± 9%	Explore
endothelial cell of vascular tree	14 studies	32% ± 15%	Explore
connective tissue cell	13 studies	28% ± 9%	Explore
glutamatergic neuron	13 studies	53% ± 24%	Explore
myofibroblast cell	13 studies	30% ± 12%	Explore
dendritic cell	12 studies	42% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	42% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	38% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	41% ± 11%	Explore
endothelial cell of artery	12 studies	30% ± 9%	Explore
vein endothelial cell	12 studies	32% ± 16%	Explore
myeloid cell	12 studies	31% ± 12%	Explore
GABAergic neuron	11 studies	54% ± 23%	Explore
mesothelial cell	11 studies	38% ± 12%	Explore
epithelial cell	11 studies	46% ± 23%	Explore
type I pneumocyte	10 studies	34% ± 9%	Explore
innate lymphoid cell	9 studies	35% ± 12%	Explore
leukocyte	9 studies	40% ± 15%	Explore
abnormal cell	9 studies	35% ± 14%	Explore
neuron	9 studies	47% ± 24%	Explore
adipocyte	9 studies	32% ± 10%	Explore
T follicular helper cell	8 studies	43% ± 9%	Explore
amacrine cell	8 studies	43% ± 13%	Explore
retinal rod cell	8 studies	35% ± 10%	Explore
secretory cell	7 studies	26% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	29% ± 8%	Explore
progenitor cell	7 studies	28% ± 10%	Explore
interneuron	7 studies	60% ± 22%	Explore
retinal ganglion cell	7 studies	32% ± 12%	Explore
club cell	7 studies	39% ± 12%	Explore
type II pneumocyte	7 studies	35% ± 9%	Explore
retinal cone cell	7 studies	33% ± 9%	Explore
neutrophil	6 studies	23% ± 9%	Explore
respiratory goblet cell	6 studies	40% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	32% ± 12%	Explore
mononuclear phagocyte	6 studies	30% ± 10%	Explore
lymphocyte	6 studies	50% ± 20%	Explore
precursor B cell	6 studies	43% ± 8%	Explore
plasma cell	6 studies	28% ± 6%	Explore
retina horizontal cell	6 studies	46% ± 10%	Explore
Mueller cell	6 studies	36% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	44% ± 18%	Explore
goblet cell	6 studies	36% ± 26%	Explore
CD4-positive helper T cell	5 studies	36% ± 18%	Explore
hematopoietic precursor cell	5 studies	41% ± 21%	Explore
retinal bipolar neuron	5 studies	38% ± 6%	Explore
glial cell	5 studies	34% ± 9%	Explore
hematopoietic stem cell	5 studies	28% ± 8%	Explore
pro-B cell	5 studies	39% ± 6%	Explore
brush cell	5 studies	33% ± 10%	Explore
cardiac muscle cell	5 studies	25% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	35% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	28% ± 8%	Explore
squamous epithelial cell	4 studies	35% ± 23%	Explore
pancreatic A cell	4 studies	34% ± 17%	Explore
exhausted T cell	4 studies	47% ± 22%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	21% ± 6%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	45% ± 9%	Explore
granule cell	4 studies	46% ± 7%	Explore
immature B cell	4 studies	40% ± 5%	Explore
retinal pigment epithelial cell	4 studies	43% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	27% ± 6%	Explore
hepatocyte	4 studies	48% ± 17%	Explore
granulocyte	4 studies	34% ± 13%	Explore
muscle cell	4 studies	39% ± 25%	Explore
enteroendocrine cell	4 studies	34% ± 11%	Explore
double negative thymocyte	4 studies	49% ± 11%	Explore
erythrocyte	4 studies	35% ± 16%	Explore
ionocyte	3 studies	32% ± 10%	Explore
type B pancreatic cell	3 studies	39% ± 16%	Explore
plasmablast	3 studies	42% ± 22%	Explore
glomerular endothelial cell	3 studies	26% ± 8%	Explore
renal alpha-intercalated cell	3 studies	25% ± 8%	Explore
neural crest cell	3 studies	25% ± 3%	Explore
GABAergic interneuron	3 studies	48% ± 4%	Explore
GABAergic amacrine cell	3 studies	51% ± 7%	Explore
OFF-bipolar cell	3 studies	41% ± 9%	Explore
ON-bipolar cell	3 studies	41% ± 7%	Explore
glycinergic amacrine cell	3 studies	49% ± 3%	Explore
rod bipolar cell	3 studies	47% ± 7%	Explore
erythroblast	3 studies	22% ± 9%	Explore
germinal center B cell	3 studies	34% ± 4%	Explore
neural progenitor cell	3 studies	48% ± 11%	Explore
ependymal cell	3 studies	59% ± 12%	Explore
adventitial cell	3 studies	32% ± 6%	Explore
alveolar macrophage	3 studies	47% ± 8%	Explore
chondrocyte	3 studies	39% ± 13%	Explore
group 3 innate lymphoid cell	3 studies	51% ± 11%	Explore
Schwann cell	3 studies	41% ± 16%	Explore
transit amplifying cell	3 studies	40% ± 34%	Explore
T-helper 17 cell	3 studies	39% ± 10%	Explore
T-helper 1 cell	3 studies	37% ± 12%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	39% ± 3%	Explore
double-positive, alpha-beta thymocyte	3 studies	50% ± 13%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	25% ± 12%	Explore
myoepithelial cell	3 studies	43% ± 12%	Explore
mural cell	3 studies	56% ± 16%	Explore
mucus secreting cell	3 studies	41% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	21 studies	47% ± 22%	Explore
lung	17 studies	32% ± 8%	Explore
peripheral blood	16 studies	36% ± 13%	Explore
intestine	10 studies	24% ± 9%	Explore
eye	10 studies	40% ± 16%	Explore
kidney	7 studies	27% ± 7%	Explore
heart	5 studies	28% ± 5%	Explore
breast	5 studies	28% ± 7%	Explore
liver	5 studies	40% ± 15%	Explore
bone marrow	4 studies	33% ± 11%	Explore
uterus	4 studies	32% ± 13%	Explore
lymph node	4 studies	35% ± 7%	Explore
adipose	4 studies	34% ± 8%	Explore
pancreas	3 studies	38% ± 15%	Explore
prostate	3 studies	25% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2590.70	1445 / 1445	100%	24.58	183 / 183
prostate	100%	3210.58	245 / 245	100%	17.96	502 / 502
lung	100%	3266.18	578 / 578	100%	17.05	1154 / 1155
breast	100%	3717.22	459 / 459	100%	28.53	1116 / 1118
brain	100%	2558.52	2637 / 2642	100%	16.29	705 / 705
thymus	100%	4182.19	653 / 653	100%	20.63	603 / 605
uterus	100%	4081.81	170 / 170	99%	14.67	456 / 459
pancreas	100%	2002.95	327 / 328	99%	15.10	177 / 178
ovary	100%	3676.41	180 / 180	99%	13.50	426 / 430
bladder	100%	3098.24	21 / 21	99%	12.22	497 / 504
stomach	100%	2391.86	359 / 359	98%	13.71	279 / 286
adrenal gland	100%	2515.16	258 / 258	97%	12.02	222 / 230
intestine	100%	2966.65	966 / 966	96%	12.00	508 / 527
kidney	100%	1903.52	89 / 89	96%	11.83	861 / 901
liver	100%	1333.12	226 / 226	92%	8.80	374 / 406
skin	100%	2784.34	1808 / 1809	88%	12.78	417 / 472
adipose	100%	3453.19	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3426.28	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	15.50	29 / 29
spleen	100%	3718.75	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	12.59	45 / 45
ureter	0%	0	0 / 0	100%	6.83	1 / 1
muscle	99%	1583.14	798 / 803	0%	0	0 / 0
heart	98%	1398.27	841 / 861	0%	0	0 / 0
peripheral blood	86%	2019.66	795 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	43%	3.06	34 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_1902455	Biological process	negative regulation of stem cell population maintenance
GO_0007283	Biological process	spermatogenesis
GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0071514	Biological process	genomic imprinting
GO_0097368	Biological process	establishment of Sertoli cell barrier
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0008150	Biological process	biological_process
GO_1902459	Biological process	positive regulation of stem cell population maintenance
GO_0030336	Biological process	negative regulation of cell migration
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005739	Cellular component	mitochondrion
GO_0070822	Cellular component	Sin3-type complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	ARID4B
Protein name	AT-rich interaction domain 4B ARID4B protein AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1)
Synonyms	RBBP1L1 RBP1L1 SAP180 BRCAA1
Description	FUNCTION: Acts as a transcriptional repressor . May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes . Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). .
Accessions	A0PJ81 ENST00000366603.6 [Q4LE39-1] ENST00000444620.2 Q4LE39 ENST00000349213.7 [Q4LE39-2] H7C5R6 X6RCR8 ENST00000474953.5 ENST00000264183.9 [Q4LE39-1] ENST00000421364.5 [Q4LE39-3] H0Y7Y8 ENST00000418304.1

ARID4B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review