I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 4 studies | 18% ± 2% | |
| epithelial cell | 3 studies | 22% ± 3% | |
| transit amplifying cell | 3 studies | 26% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 4 studies | 18% ± 2% | |
| epithelial cell | 3 studies | 22% ± 3% | |
| transit amplifying cell | 3 studies | 26% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2961.41 | 1445 / 1445 | 100% | 54.99 | 183 / 183 |
| liver | 100% | 2598.90 | 226 / 226 | 100% | 36.84 | 406 / 406 |
| ovary | 100% | 3089.82 | 180 / 180 | 100% | 39.47 | 430 / 430 |
| pancreas | 100% | 2274.12 | 328 / 328 | 100% | 40.73 | 178 / 178 |
| prostate | 100% | 2922.83 | 245 / 245 | 100% | 48.33 | 502 / 502 |
| stomach | 100% | 2327.89 | 359 / 359 | 100% | 55.38 | 286 / 286 |
| uterus | 100% | 2944.32 | 170 / 170 | 100% | 66.14 | 459 / 459 |
| intestine | 100% | 2807.41 | 966 / 966 | 100% | 62.34 | 526 / 527 |
| bladder | 100% | 2696.62 | 21 / 21 | 100% | 53.88 | 503 / 504 |
| skin | 100% | 3577.30 | 1809 / 1809 | 100% | 48.85 | 471 / 472 |
| brain | 100% | 2461.27 | 2636 / 2642 | 100% | 50.27 | 705 / 705 |
| lung | 100% | 2403.46 | 577 / 578 | 100% | 50.58 | 1154 / 1155 |
| breast | 100% | 2592.24 | 459 / 459 | 100% | 54.69 | 1114 / 1118 |
| thymus | 100% | 2757.49 | 653 / 653 | 99% | 38.52 | 601 / 605 |
| kidney | 100% | 2226.46 | 89 / 89 | 99% | 33.32 | 890 / 901 |
| adrenal gland | 100% | 2500.43 | 258 / 258 | 97% | 30.28 | 222 / 230 |
| adipose | 100% | 2463.26 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 42.19 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 56.65 | 29 / 29 |
| muscle | 100% | 2859.70 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2940.83 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 74.40 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 47.68 | 1 / 1 |
| blood vessel | 100% | 2105.13 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 1632.57 | 852 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 81% | 1479.90 | 755 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045995 | Biological process | regulation of embryonic development |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0090043 | Biological process | regulation of tubulin deacetylation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0051302 | Biological process | regulation of cell division |
| GO_0045722 | Biological process | positive regulation of gluconeogenesis |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0006094 | Biological process | gluconeogenesis |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0045815 | Biological process | transcription initiation-coupled chromatin remodeling |
| GO_0001501 | Biological process | skeletal system development |
| GO_0051726 | Biological process | regulation of cell cycle |
| GO_0035097 | Cellular component | histone methyltransferase complex |
| GO_0044545 | Cellular component | NSL complex |
| GO_0071339 | Cellular component | MLL1 complex |
| GO_0072686 | Cellular component | mitotic spindle |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0044665 | Cellular component | MLL1/2 complex |
| GO_0044666 | Cellular component | MLL3/4 complex |
| GO_0140672 | Cellular component | ATAC complex |
| GO_0048188 | Cellular component | Set1C/COMPASS complex |
| GO_0000123 | Cellular component | histone acetyltransferase complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0035064 | Molecular function | methylated histone binding |
| GO_0042800 | Molecular function | histone H3K4 methyltransferase activity |
| GO_0042393 | Molecular function | histone binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | WDR5 |
| Protein name | WD repeat domain 5 WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) |
| Synonyms | BIG3 |
| Description | FUNCTION: Contributes to histone modification . May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' . As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 . H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation . As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues . May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B . . |
| Accessions | ENST00000608937.5 P61964 V9GZ59 V9GYQ5 ENST00000608739.5 ENST00000358625.4 |
