CNOT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060213Biological processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0001829Biological processtrophectodermal cell differentiation
GO_0010606Biological processpositive regulation of cytoplasmic mRNA processing body assembly
GO_2000036Biological processregulation of stem cell population maintenance
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0048387Biological processnegative regulation of retinoic acid receptor signaling pathway
GO_0033147Biological processnegative regulation of intracellular estrogen receptor signaling pathway
GO_0035195Biological processmiRNA-mediated post-transcriptional gene silencing
GO_1900153Biological processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0000289Biological processnuclear-transcribed mRNA poly(A) tail shortening
GO_0000288Biological processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0061014Biological processpositive regulation of mRNA catabolic process
GO_0017148Biological processnegative regulation of translation
GO_0005615Cellular componentextracellular space
GO_0030015Cellular componentCCR4-NOT core complex
GO_0016020Cellular componentmembrane
GO_0000932Cellular componentP-body
GO_0030014Cellular componentCCR4-NOT complex
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0019904Molecular functionprotein domain specific binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0042974Molecular functionnuclear retinoic acid receptor binding
GO_0003723Molecular functionRNA binding
GO_0004535Molecular functionpoly(A)-specific ribonuclease activity
GO_0005515Molecular functionprotein binding
GO_0070016Molecular functionarmadillo repeat domain binding

IV. Literature review

[source]
Gene nameCNOT1
Protein nameCCR4-NOT transcription complex subunit 1
CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1)
SynonymsCDC39
AD-005
KIAA1007
NOT1
DescriptionFUNCTION: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. .

AccessionsH3BMH0
ENST00000569882.1
ENST00000568917.1
ENST00000569020.5
H3BVC9
ENST00000567285.1
ENST00000564557.1
ENST00000567133.1
H3BU44
H3BR89
ENST00000565605.5
ENST00000569240.5 [A5YKK6-2]
ENST00000565697.1
H3BTH2
ENST00000317147.10 [A5YKK6-1]
H3BMZ2
ENST00000567188.5 [A5YKK6-3]
ENST00000562046.1
ENST00000441024.6 [A5YKK6-4]
H3BNB1
H3BT18
A5YKK6
H3BPF1
ENST00000566240.1