ARID4A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_1902455Biological processnegative regulation of stem cell population maintenance
GO_0048821Biological processerythrocyte development
GO_0007283Biological processspermatogenesis
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0071514Biological processgenomic imprinting
GO_0097368Biological processestablishment of Sertoli cell barrier
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0030336Biological processnegative regulation of cell migration
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0070822Cellular componentSin3-type complex
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding

IV. Literature review

[source]
Gene nameARID4A
Protein nameAT-rich interaction domain 4A
ARID4A protein
AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1)
SynonymsRBBP1
RBP1
DescriptionFUNCTION: DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex . Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). .

AccessionsH7C485
C9J1W3
ENST00000431317.6 [P29374-3]
ENST00000445108.5
C9JIF4
ENST00000348476.7 [P29374-3]
F8WAR5
ENST00000417477.2
ENST00000395168.7 [P29374-2]
Q05CG0
ENST00000355431.8 [P29374-1]
P29374
ENST00000424658.5
ENST00000431612.5