INSM1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of INSM1 at tissue level.

III. Associated gene sets

GO_0003309Biological processtype B pancreatic cell differentiation
GO_0010468Biological processregulation of gene expression
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0008283Biological processcell population proliferation
GO_0042421Biological processnorepinephrine biosynthetic process
GO_0003310Biological processpancreatic A cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0061549Biological processsympathetic ganglion development
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0030182Biological processneuron differentiation
GO_0045597Biological processpositive regulation of cell differentiation
GO_2000179Biological processpositive regulation of neural precursor cell proliferation
GO_0061104Biological processadrenal chromaffin cell differentiation
GO_0030335Biological processpositive regulation of cell migration
GO_0010564Biological processregulation of cell cycle process
GO_0003323Biological processtype B pancreatic cell development
GO_0043254Biological processregulation of protein-containing complex assembly
GO_0060290Biological processtransdifferentiation
GO_0003358Biological processnoradrenergic neuron development
GO_0016477Biological processcell migration
GO_0051726Biological processregulation of cell cycle
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0060090Molecular functionmolecular adaptor activity
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0031490Molecular functionchromatin DNA binding
GO_0030332Molecular functioncyclin binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameINSM1
Protein nameInsulinoma-associated protein 1 (Zinc finger protein IA-1)
SynonymsIA1
DescriptionFUNCTION: Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' . Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation. .

AccessionsQ01101
ENST00000310227.3