SNAI1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SNAI1 at tissue level.

III. Associated gene sets

GO_0001837Biological processepithelial to mesenchymal transition
GO_0003198Biological processepithelial to mesenchymal transition involved in endocardial cushion formation
GO_0007219Biological processNotch signaling pathway
GO_0060806Biological processnegative regulation of cell differentiation involved in embryonic placenta development
GO_0010631Biological processepithelial cell migration
GO_0001649Biological processosteoblast differentiation
GO_0031069Biological processhair follicle morphogenesis
GO_0003180Biological processaortic valve morphogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0060536Biological processcartilage morphogenesis
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0060707Biological processtrophoblast giant cell differentiation
GO_0060972Biological processleft/right pattern formation
GO_0070828Biological processheterochromatin organization
GO_0060021Biological processroof of mouth development
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001707Biological processmesoderm formation
GO_0030335Biological processpositive regulation of cell migration
GO_2000810Biological processregulation of bicellular tight junction assembly
GO_1902230Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_0006355Biological processregulation of DNA-templated transcription
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0010957Biological processnegative regulation of vitamin D biosynthetic process
GO_0043518Biological processnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0005829Cellular componentcytosol
GO_0005721Cellular componentpericentric heterochromatin
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0019900Molecular functionkinase binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0046872Molecular functionmetal ion binding
GO_0070888Molecular functionE-box binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSNAI1
Protein nameZinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna)
SynonymsSNAH
DescriptionFUNCTION: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription . The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) . During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. .

AccessionsENST00000244050.3
O95863