SLA2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLA2 at tissue level.

III. Associated gene sets

GO_0050851Biological processantigen receptor-mediated signaling pathway
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050776Biological processregulation of immune response
GO_0050849Biological processnegative regulation of calcium-mediated signaling
GO_0019724Biological processB cell mediated immunity
GO_0042110Biological processT cell activation
GO_0005886Cellular componentplasma membrane
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005770Cellular componentlate endosome
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0046935Molecular function1-phosphatidylinositol-3-kinase regulator activity
GO_0035591Molecular functionsignaling adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLA2
Protein nameSrc-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)
SynonymsC20orf156
SLAP2
DescriptionFUNCTION: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. .

AccessionsENST00000262866.9 [Q9H6Q3-1]
Q9H6Q3
ENST00000360672.2 [Q9H6Q3-2]