Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 26 studies | 25% ± 7% | |
CD16-negative, CD56-bright natural killer cell, human | 12 studies | 28% ± 11% | |
CD16-positive, CD56-dim natural killer cell, human | 12 studies | 28% ± 7% | |
gamma-delta T cell | 11 studies | 28% ± 11% | |
CD8-positive, alpha-beta T cell | 11 studies | 20% ± 4% | |
CD8-positive, alpha-beta memory T cell | 10 studies | 23% ± 4% | |
mature NK T cell | 9 studies | 21% ± 5% | |
platelet | 8 studies | 27% ± 7% | |
plasmacytoid dendritic cell | 8 studies | 25% ± 7% | |
T cell | 6 studies | 18% ± 2% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 4 studies | 18% ± 2% | |
innate lymphoid cell | 3 studies | 19% ± 1% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 23% ± 3% |
Insufficient scRNA-seq data for expression of SLA2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 488.79 | 578 / 578 | 93% | 4.84 | 1069 / 1155 |
stomach | 90% | 108.07 | 322 / 359 | 81% | 3.82 | 233 / 286 |
prostate | 91% | 92.23 | 224 / 245 | 76% | 1.80 | 381 / 502 |
breast | 80% | 76.09 | 366 / 459 | 77% | 4.05 | 859 / 1118 |
thymus | 89% | 95.12 | 581 / 653 | 65% | 6.87 | 392 / 605 |
intestine | 70% | 140.00 | 681 / 966 | 79% | 2.77 | 414 / 527 |
uterus | 71% | 42.65 | 120 / 170 | 76% | 4.53 | 348 / 459 |
kidney | 62% | 53.40 | 55 / 89 | 80% | 4.61 | 722 / 901 |
liver | 78% | 57.65 | 176 / 226 | 52% | 1.58 | 212 / 406 |
esophagus | 52% | 31.11 | 746 / 1445 | 77% | 3.03 | 140 / 183 |
bladder | 62% | 65.24 | 13 / 21 | 66% | 2.75 | 331 / 504 |
pancreas | 18% | 8.68 | 60 / 328 | 87% | 3.60 | 155 / 178 |
skin | 33% | 15.67 | 605 / 1809 | 72% | 5.74 | 339 / 472 |
lymph node | 0% | 0 | 0 / 0 | 100% | 20.85 | 29 / 29 |
spleen | 100% | 944.58 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 2292.59 | 911 / 929 | 0% | 0 | 0 / 0 |
ovary | 38% | 19.71 | 69 / 180 | 59% | 1.63 | 252 / 430 |
tonsil | 0% | 0 | 0 / 0 | 91% | 8.89 | 41 / 45 |
adipose | 89% | 108.43 | 1068 / 1204 | 0% | 0 | 0 / 0 |
adrenal gland | 55% | 26.97 | 143 / 258 | 21% | 0.44 | 48 / 230 |
heart | 71% | 42.38 | 611 / 861 | 0% | 0 | 0 / 0 |
brain | 42% | 24.30 | 1097 / 2642 | 18% | 0.38 | 126 / 705 |
blood vessel | 59% | 53.70 | 783 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 20% | 0.88 | 16 / 80 |
muscle | 16% | 6.64 | 130 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0050851 | Biological process | antigen receptor-mediated signaling pathway |
GO_0050860 | Biological process | negative regulation of T cell receptor signaling pathway |
GO_0046854 | Biological process | phosphatidylinositol phosphate biosynthetic process |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0050776 | Biological process | regulation of immune response |
GO_0050849 | Biological process | negative regulation of calcium-mediated signaling |
GO_0019724 | Biological process | B cell mediated immunity |
GO_0042110 | Biological process | T cell activation |
GO_0005886 | Cellular component | plasma membrane |
GO_0005942 | Cellular component | phosphatidylinositol 3-kinase complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005829 | Cellular component | cytosol |
GO_0005770 | Cellular component | late endosome |
GO_0005737 | Cellular component | cytoplasm |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0010008 | Cellular component | endosome membrane |
GO_0046935 | Molecular function | 1-phosphatidylinositol-3-kinase regulator activity |
GO_0035591 | Molecular function | signaling adaptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | SLA2 |
Protein name | Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2) |
Synonyms | C20orf156 SLAP2 |
Description | FUNCTION: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. . |
Accessions | ENST00000262866.9 [Q9H6Q3-1] Q9H6Q3 ENST00000360672.2 [Q9H6Q3-2] |