E2F1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of E2F1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of E2F1 at tissue level.

III. Associated gene sets

GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_1990086Biological processlens fiber cell apoptotic process
GO_0070345Biological processnegative regulation of fat cell proliferation
GO_0030900Biological processforebrain development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0043276Biological processanoikis
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0048255Biological processmRNA stabilization
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006351Biological processDNA-templated transcription
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0006355Biological processregulation of DNA-templated transcription
GO_0043392Biological processnegative regulation of DNA binding
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000077Biological processDNA damage checkpoint signaling
GO_0035189Cellular componentRb-E2F complex
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0060090Molecular functionmolecular adaptor activity
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001216Molecular functionDNA-binding transcription activator activity
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameE2F1
Protein nameTranscription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
SynonymsRBBP3
DescriptionFUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication . The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase . E2F1 binds preferentially RB1 in a cell-cycle dependent manner . It can mediate both cell proliferation and TP53/p53-dependent apoptosis . Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters . Directly activates transcription of PEG10 . Positively regulates transcription of RRP1B . .

AccessionsQ01094
ENST00000343380.6