Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 23 studies | 33% ± 15% | |
| macrophage | 22 studies | 29% ± 16% | |
| fibroblast | 12 studies | 29% ± 12% | |
| glutamatergic neuron | 11 studies | 40% ± 25% | |
| microglial cell | 11 studies | 38% ± 12% | |
| astrocyte | 10 studies | 32% ± 14% | |
| oligodendrocyte | 10 studies | 36% ± 13% | |
| ciliated cell | 9 studies | 28% ± 14% | |
| oligodendrocyte precursor cell | 9 studies | 33% ± 14% | |
| B cell | 8 studies | 21% ± 6% | |
| GABAergic neuron | 8 studies | 44% ± 22% | |
| pericyte | 8 studies | 26% ± 11% | |
| myeloid cell | 8 studies | 33% ± 5% | |
| epithelial cell | 8 studies | 40% ± 23% | |
| adipocyte | 8 studies | 29% ± 7% | |
| neuron | 7 studies | 37% ± 15% | |
| basal cell | 7 studies | 30% ± 19% | |
| monocyte | 7 studies | 29% ± 9% | |
| smooth muscle cell | 7 studies | 24% ± 5% | |
| T cell | 6 studies | 20% ± 5% | |
| natural killer cell | 6 studies | 20% ± 4% | |
| interneuron | 6 studies | 45% ± 22% | |
| club cell | 6 studies | 26% ± 7% | |
| retina horizontal cell | 6 studies | 22% ± 11% | |
| dendritic cell | 6 studies | 29% ± 8% | |
| endothelial cell of lymphatic vessel | 6 studies | 33% ± 14% | |
| type II pneumocyte | 6 studies | 23% ± 7% | |
| type I pneumocyte | 6 studies | 25% ± 9% | |
| classical monocyte | 5 studies | 20% ± 6% | |
| CD4-positive, alpha-beta T cell | 5 studies | 19% ± 2% | |
| effector memory CD8-positive, alpha-beta T cell | 5 studies | 19% ± 2% | |
| amacrine cell | 5 studies | 20% ± 9% | |
| respiratory goblet cell | 5 studies | 30% ± 12% | |
| mast cell | 5 studies | 27% ± 10% | |
| goblet cell | 5 studies | 32% ± 23% | |
| retinal ganglion cell | 4 studies | 34% ± 12% | |
| retinal bipolar neuron | 4 studies | 16% ± 1% | |
| cardiac muscle cell | 4 studies | 18% ± 1% | |
| mesothelial cell | 4 studies | 28% ± 4% | |
| lymphocyte | 4 studies | 36% ± 14% | |
| Mueller cell | 4 studies | 25% ± 12% | |
| retinal rod cell | 4 studies | 21% ± 6% | |
| CD8-positive, alpha-beta T cell | 4 studies | 18% ± 1% | |
| secretory cell | 4 studies | 17% ± 2% | |
| regulatory T cell | 4 studies | 18% ± 3% | |
| hepatocyte | 4 studies | 58% ± 21% | |
| ionocyte | 3 studies | 24% ± 6% | |
| GABAergic interneuron | 3 studies | 31% ± 6% | |
| glial cell | 3 studies | 24% ± 6% | |
| granule cell | 3 studies | 25% ± 4% | |
| naive B cell | 3 studies | 17% ± 0% | |
| plasma cell | 3 studies | 29% ± 6% | |
| squamous epithelial cell | 3 studies | 34% ± 22% | |
| retinal cone cell | 3 studies | 24% ± 6% | |
| retinal pigment epithelial cell | 3 studies | 43% ± 21% | |
| CD16-negative, CD56-bright natural killer cell, human | 3 studies | 17% ± 1% | |
| mononuclear phagocyte | 3 studies | 29% ± 8% | |
| tissue-resident macrophage | 3 studies | 25% ± 10% | |
| vein endothelial cell | 3 studies | 33% ± 21% | |
| glycinergic amacrine cell | 3 studies | 21% ± 6% | |
| rod bipolar cell | 3 studies | 25% ± 12% | |
| CD8-positive, alpha-beta memory T cell | 3 studies | 17% ± 0% | |
| cholangiocyte | 3 studies | 49% ± 16% | |
| abnormal cell | 3 studies | 33% ± 16% | |
| ependymal cell | 3 studies | 31% ± 16% | |
| enteroendocrine cell | 3 studies | 19% ± 3% | |
| leukocyte | 3 studies | 28% ± 8% | |
| alveolar macrophage | 3 studies | 44% ± 13% | |
| capillary endothelial cell | 3 studies | 20% ± 4% | |
| muscle cell | 3 studies | 32% ± 22% | |
| transit amplifying cell | 3 studies | 38% ± 29% | |
| renal alpha-intercalated cell | 3 studies | 22% ± 6% | |
| renal principal cell | 3 studies | 22% ± 4% | |
| mural cell | 3 studies | 35% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 8681.34 | 1445 / 1445 | 100% | 56.74 | 183 / 183 |
| breast | 100% | 7398.93 | 459 / 459 | 100% | 55.74 | 1116 / 1118 |
| lung | 100% | 8411.14 | 578 / 578 | 100% | 37.42 | 1152 / 1155 |
| brain | 100% | 5664.76 | 2634 / 2642 | 100% | 40.06 | 705 / 705 |
| stomach | 100% | 6603.15 | 359 / 359 | 100% | 44.68 | 285 / 286 |
| intestine | 100% | 8051.53 | 966 / 966 | 99% | 38.23 | 524 / 527 |
| bladder | 100% | 8577.90 | 21 / 21 | 99% | 34.44 | 501 / 504 |
| prostate | 100% | 5993.00 | 245 / 245 | 99% | 31.03 | 499 / 502 |
| uterus | 100% | 8273.10 | 170 / 170 | 99% | 40.39 | 456 / 459 |
| thymus | 100% | 7561.30 | 653 / 653 | 99% | 38.34 | 600 / 605 |
| pancreas | 100% | 4525.37 | 327 / 328 | 99% | 33.95 | 177 / 178 |
| ovary | 100% | 6820.97 | 180 / 180 | 99% | 34.21 | 424 / 430 |
| kidney | 100% | 5340.36 | 89 / 89 | 99% | 37.41 | 888 / 901 |
| adrenal gland | 100% | 9493.55 | 258 / 258 | 98% | 30.48 | 226 / 230 |
| skin | 100% | 8811.81 | 1808 / 1809 | 98% | 41.29 | 462 / 472 |
| liver | 100% | 5078.30 | 226 / 226 | 98% | 25.97 | 397 / 406 |
| adipose | 100% | 8093.20 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 9015.98 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 32.13 | 29 / 29 |
| muscle | 100% | 12011.78 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 6596.94 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.09 | 1 / 1 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 35.75 | 44 / 45 |
| peripheral blood | 97% | 6482.60 | 900 / 929 | 0% | 0 | 0 / 0 |
| heart | 95% | 5496.13 | 818 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 94% | 21.89 | 75 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0060271 | Biological process | cilium assembly |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0032435 | Biological process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0032092 | Biological process | positive regulation of protein binding |
| GO_0071947 | Biological process | protein deubiquitination involved in ubiquitin-dependent protein catabolic process |
| GO_0051301 | Biological process | cell division |
| GO_0001764 | Biological process | neuron migration |
| GO_0016562 | Biological process | protein import into peroxisome matrix, receptor recycling |
| GO_0035520 | Biological process | monoubiquitinated protein deubiquitination |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0042752 | Biological process | regulation of circadian rhythm |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0006307 | Biological process | DNA alkylation repair |
| GO_1990000 | Biological process | amyloid fibril formation |
| GO_0070536 | Biological process | protein K63-linked deubiquitination |
| GO_0050821 | Biological process | protein stabilization |
| GO_1904515 | Biological process | positive regulation of TORC2 signaling |
| GO_0016579 | Biological process | protein deubiquitination |
| GO_0048675 | Biological process | axon extension |
| GO_0008104 | Biological process | protein localization |
| GO_0061824 | Biological process | cytosolic ciliogenesis |
| GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
| GO_0048511 | Biological process | rhythmic process |
| GO_0016477 | Biological process | cell migration |
| GO_0007292 | Biological process | female gamete generation |
| GO_0016020 | Cellular component | membrane |
| GO_0005813 | Cellular component | centrosome |
| GO_0005929 | Cellular component | cilium |
| GO_0005829 | Cellular component | cytosol |
| GO_0030426 | Cellular component | growth cone |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0101005 | Molecular function | deubiquitinase activity |
| GO_0180017 | Molecular function | K11-linked deubiquitinase activity |
| GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
| GO_0070410 | Molecular function | co-SMAD binding |
| GO_1990380 | Molecular function | K48-linked deubiquitinase activity |
| GO_0061578 | Molecular function | K63-linked deubiquitinase activity |
| GO_0008234 | Molecular function | cysteine-type peptidase activity |
| GO_0004197 | Molecular function | cysteine-type endopeptidase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0140313 | Molecular function | molecular sequestering activity |
| Gene name | USP9X |
| Protein name | Ubiquitin specific peptidase 9 X-linked Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X) USP9X protein ubiquitinyl hydrolase 1 (EC 3.4.19.12) |
| Synonyms | USP9 DFFRX FAM |
| Description | FUNCTION: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins . May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin . Specifically hydrolyzes 'Lys-63'-, 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains . Essential component of TGF-beta/BMP signaling cascade . Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 . Deubiquitinates alkylation repair enzyme ALKBH3 . OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions . Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembly . Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres . Involved in axonal growth and neuronal cell migration . Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein BMAL1 via its deubiquitinating activity . Acts as a regulator of peroxisome import by mediating deubiquitination of PEX5: specifically deubiquitinates PEX5 monoubiquitinated at 'Cys-11' following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle . Deubiquitinates PEG10 (By similarity). . |
| Accessions | A0A994J6S4 ENST00000704653.1 ENST00000703986.1 ENST00000704654.1 A0A994J7K1 Q86X58 ENST00000324545.9 [Q93008-3] Q93008 ENST00000704650.1 [Q93008-1] ENST00000704656.1 ENST00000704652.1 ENST00000704655.1 Q6P468 A0A994J588 ENST00000704649.1 A0A994J583 A0A994J4T3 A0A994J766 ENST00000704651.1 ENST00000703987.1 A0A994J4K9 ENST00000378308.7 [Q93008-1] A0A994J4T8 A0A994J4R6 |