USP9X report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0016567Biological processprotein ubiquitination
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0007059Biological processchromosome segregation
GO_0032092Biological processpositive regulation of protein binding
GO_0071947Biological processprotein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO_0051301Biological processcell division
GO_0001764Biological processneuron migration
GO_0016562Biological processprotein import into peroxisome matrix, receptor recycling
GO_0035520Biological processmonoubiquitinated protein deubiquitination
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0042752Biological processregulation of circadian rhythm
GO_0030509Biological processBMP signaling pathway
GO_0006307Biological processDNA alkylation repair
GO_1990000Biological processamyloid fibril formation
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0050821Biological processprotein stabilization
GO_1904515Biological processpositive regulation of TORC2 signaling
GO_0016579Biological processprotein deubiquitination
GO_0048675Biological processaxon extension
GO_0008104Biological processprotein localization
GO_0061824Biological processcytosolic ciliogenesis
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0048511Biological processrhythmic process
GO_0016477Biological processcell migration
GO_0007292Biological processfemale gamete generation
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0101005Molecular functiondeubiquitinase activity
GO_0180017Molecular functionK11-linked deubiquitinase activity
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0070410Molecular functionco-SMAD binding
GO_1990380Molecular functionK48-linked deubiquitinase activity
GO_0061578Molecular functionK63-linked deubiquitinase activity
GO_0008234Molecular functioncysteine-type peptidase activity
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0140313Molecular functionmolecular sequestering activity

IV. Literature review

[source]
Gene nameUSP9X
Protein nameUbiquitin specific peptidase 9 X-linked
Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)
USP9X protein
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
SynonymsUSP9
DFFRX
FAM
DescriptionFUNCTION: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins . May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin . Specifically hydrolyzes 'Lys-63'-, 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains . Essential component of TGF-beta/BMP signaling cascade . Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 . Deubiquitinates alkylation repair enzyme ALKBH3 . OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions . Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembly . Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres . Involved in axonal growth and neuronal cell migration . Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein BMAL1 via its deubiquitinating activity . Acts as a regulator of peroxisome import by mediating deubiquitination of PEX5: specifically deubiquitinates PEX5 monoubiquitinated at 'Cys-11' following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle . Deubiquitinates PEG10 (By similarity). .

AccessionsA0A994J6S4
ENST00000704653.1
ENST00000703986.1
ENST00000704654.1
A0A994J7K1
Q86X58
ENST00000324545.9 [Q93008-3]
Q93008
ENST00000704650.1 [Q93008-1]
ENST00000704656.1
ENST00000704652.1
ENST00000704655.1
Q6P468
A0A994J588
ENST00000704649.1
A0A994J583
A0A994J4T3
A0A994J766
ENST00000704651.1
ENST00000703987.1
A0A994J4K9
ENST00000378308.7 [Q93008-1]
A0A994J4T8
A0A994J4R6