FNIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0008285Biological processnegative regulation of cell population proliferation
GO_2000973Biological processregulation of pro-B cell differentiation
GO_0001783Biological processB cell apoptotic process
GO_0031929Biological processTOR signaling
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0032007Biological processnegative regulation of TOR signaling
GO_0001932Biological processregulation of protein phosphorylation
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0009267Biological processcellular response to starvation
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_1905672Biological processnegative regulation of lysosome organization
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0002327Biological processimmature B cell differentiation
GO_0002904Biological processpositive regulation of B cell apoptotic process
GO_0032008Biological processpositive regulation of TOR signaling
GO_0030183Biological processB cell differentiation
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005765Cellular componentlysosomal membrane
GO_0019899Molecular functionenzyme binding
GO_0008047Molecular functionenzyme activator activity
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0042030Molecular functionATPase inhibitor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFNIP1
Protein nameFolliculin-interacting protein 1
Folliculin interacting protein 1
SynonymsKIAA1961
DescriptionFUNCTION: Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 . Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling . In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 . Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy . In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 . Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 . Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins . Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development . .

AccessionsJ3KNG8
ENST00000307954.12
ENST00000511848.1 [Q8TF40-2]
ENST00000307968.11 [Q8TF40-3]
Q8TF40
ENST00000510461.6 [Q8TF40-1]