KLF2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	46 studies	47% ± 22%	Explore
B cell	37 studies	49% ± 23%	Explore
natural killer cell	37 studies	42% ± 21%	Explore
classical monocyte	24 studies	37% ± 15%	Explore
CD4-positive, alpha-beta T cell	24 studies	45% ± 23%	Explore
macrophage	23 studies	36% ± 14%	Explore
non-classical monocyte	23 studies	59% ± 19%	Explore
CD8-positive, alpha-beta T cell	22 studies	40% ± 21%	Explore
fibroblast	20 studies	35% ± 17%	Explore
T cell	19 studies	39% ± 14%	Explore
monocyte	19 studies	34% ± 16%	Explore
smooth muscle cell	19 studies	33% ± 18%	Explore
memory B cell	19 studies	51% ± 21%	Explore
naive B cell	19 studies	52% ± 20%	Explore
endothelial cell of lymphatic vessel	18 studies	45% ± 20%	Explore
pericyte	18 studies	49% ± 26%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	53% ± 22%	Explore
mature NK T cell	17 studies	41% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	45% ± 23%	Explore
regulatory T cell	16 studies	46% ± 21%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	55% ± 21%	Explore
mast cell	15 studies	31% ± 14%	Explore
endothelial cell of artery	15 studies	53% ± 15%	Explore
capillary endothelial cell	15 studies	45% ± 10%	Explore
endothelial cell of vascular tree	14 studies	46% ± 21%	Explore
gamma-delta T cell	13 studies	45% ± 19%	Explore
mucosal invariant T cell	13 studies	44% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	53% ± 25%	Explore
vein endothelial cell	13 studies	48% ± 16%	Explore
plasma cell	12 studies	45% ± 14%	Explore
conventional dendritic cell	12 studies	31% ± 16%	Explore
neutrophil	11 studies	29% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	54% ± 28%	Explore
plasmablast	10 studies	49% ± 19%	Explore
myeloid cell	10 studies	37% ± 19%	Explore
dendritic cell	9 studies	23% ± 7%	Explore
innate lymphoid cell	9 studies	48% ± 21%	Explore
connective tissue cell	8 studies	28% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	58% ± 29%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	53% ± 20%	Explore
IgA plasma cell	6 studies	24% ± 4%	Explore
ciliated cell	6 studies	23% ± 6%	Explore
alveolar macrophage	5 studies	33% ± 15%	Explore
precursor B cell	5 studies	36% ± 11%	Explore
immature B cell	5 studies	62% ± 16%	Explore
mesothelial cell	5 studies	41% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	70% ± 25%	Explore
type I pneumocyte	4 studies	23% ± 7%	Explore
CD4-positive helper T cell	4 studies	35% ± 13%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	63% ± 25%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	43% ± 14%	Explore
hematopoietic precursor cell	4 studies	31% ± 9%	Explore
platelet	4 studies	40% ± 26%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	32% ± 26%	Explore
leukocyte	4 studies	43% ± 14%	Explore
mononuclear phagocyte	4 studies	32% ± 7%	Explore
glomerular endothelial cell	4 studies	68% ± 11%	Explore
adventitial cell	4 studies	30% ± 9%	Explore
double negative thymocyte	4 studies	47% ± 31%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	33% ± 8%	Explore
lymphocyte	3 studies	35% ± 14%	Explore
intermediate monocyte	3 studies	51% ± 24%	Explore
muscle cell	3 studies	25% ± 6%	Explore
hematopoietic stem cell	3 studies	23% ± 5%	Explore
myofibroblast cell	3 studies	47% ± 19%	Explore
group 3 innate lymphoid cell	3 studies	50% ± 24%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	65% ± 30%	Explore
IgG plasma cell	3 studies	24% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	51% ± 17%	Explore
lung	11 studies	29% ± 14%	Explore
intestine	6 studies	28% ± 8%	Explore
lymph node	5 studies	40% ± 13%	Explore
breast	4 studies	22% ± 7%	Explore
liver	4 studies	30% ± 9%	Explore
kidney	3 studies	26% ± 6%	Explore
bone marrow	3 studies	45% ± 16%	Explore
uterus	3 studies	43% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	99%	9535.97	455 / 459	96%	39.78	1069 / 1118
thymus	94%	4835.00	616 / 653	97%	37.57	584 / 605
ovary	99%	12270.87	178 / 180	86%	24.37	369 / 430
prostate	87%	3616.00	212 / 245	97%	32.83	487 / 502
stomach	90%	4458.07	324 / 359	92%	61.19	262 / 286
lung	98%	9437.47	567 / 578	82%	29.57	952 / 1155
esophagus	80%	4930.72	1151 / 1445	98%	55.15	180 / 183
bladder	100%	7241.10	21 / 21	76%	19.49	382 / 504
intestine	84%	3883.31	811 / 966	90%	38.48	476 / 527
kidney	85%	3147.20	76 / 89	87%	36.48	785 / 901
uterus	96%	6354.42	163 / 170	71%	15.24	328 / 459
skin	69%	3612.43	1240 / 1809	84%	19.04	397 / 472
adrenal gland	56%	1687.11	144 / 258	78%	24.74	180 / 230
brain	22%	463.19	570 / 2642	95%	18.48	670 / 705
pancreas	5%	110.02	18 / 328	96%	74.46	171 / 178
spleen	100%	5951.57	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	47.74	1 / 1
adipose	99%	12688.59	1190 / 1204	0%	0	0 / 0
blood vessel	98%	9525.94	1309 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	42.18	28 / 29
heart	93%	4558.08	804 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	89%	17.62	40 / 45
peripheral blood	86%	11508.74	800 / 929	0%	0	0 / 0
muscle	71%	2248.91	567 / 803	0%	0	0 / 0
liver	4%	154.91	10 / 226	57%	10.96	233 / 406
eye	0%	0	0 / 0	61%	9.63	49 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1901653	Biological process	cellular response to peptide
GO_0048386	Biological process	positive regulation of retinoic acid receptor signaling pathway
GO_0051247	Biological process	positive regulation of protein metabolic process
GO_0043249	Biological process	erythrocyte maturation
GO_0001701	Biological process	in utero embryonic development
GO_0071498	Biological process	cellular response to fluid shear stress
GO_0032715	Biological process	negative regulation of interleukin-6 production
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0035264	Biological process	multicellular organism growth
GO_0071347	Biological process	cellular response to interleukin-1
GO_1903671	Biological process	negative regulation of sprouting angiogenesis
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0097533	Biological process	cellular stress response to acid chemical
GO_0071409	Biological process	cellular response to cycloheximide
GO_0060509	Biological process	type I pneumocyte differentiation
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0045429	Biological process	positive regulation of nitric oxide biosynthetic process
GO_0000902	Biological process	cell morphogenesis
GO_0071499	Biological process	cellular response to laminar fluid shear stress
GO_0040029	Biological process	epigenetic regulation of gene expression
GO_0042311	Biological process	vasodilation
GO_0070301	Biological process	cellular response to hydrogen peroxide
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	KLF2
Protein name	KLF transcription factor 2 Krueppel-like factor 2 (Lung krueppel-like factor)
Synonyms	LKLF
Description	FUNCTION: Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription . Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements . .
Accessions	Q9Y5W3 K7EJ60 ENST00000248071.6 ENST00000592003.1

KLF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review