MNX1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MNX1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MNX1 at tissue level.

III. Associated gene sets

GO_0048812Biological processneuron projection morphogenesis
GO_0021520Biological processspinal cord motor neuron cell fate specification
GO_0031018Biological processendocrine pancreas development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007417Biological processcentral nervous system development
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameMNX1
Protein nameMotor neuron and pancreas homeobox 1
Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9)
SynonymsHLXB9
DescriptionFUNCTION: Transcription factor (By similarity). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity). .

AccessionsENST00000425745.1
C9K088
ENST00000474448.1
S4R3G1
ENST00000252971.11 [P50219-1]
C9JFT4
ENST00000428439.1
ENST00000543409.5 [P50219-2]
P50219
ENST00000479817.1
ENST00000469500.5
S4R364
S4R464