UBE2D1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000209Biological processprotein polyubiquitination
GO_1902916Biological processpositive regulation of protein polyubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000151Cellular componentubiquitin ligase complex
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005524Molecular functionATP binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061631Molecular functionubiquitin conjugating enzyme activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBE2D1
Protein nameUbiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
E2 ubiquitin-conjugating enzyme (EC 2.3.2.23)
SynonymsUBC5A
SFT
UBCH5
UBCH5A
DescriptionFUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins . In vitro catalyzes 'Lys-48'-linked polyubiquitination . Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 . Ubiquitinates STUB1-associated HSP90AB1 in vitro . Lacks inherent specificity for any particular lysine residue of ubiquitin . Essential for viral activation of IRF3 . Mediates polyubiquitination of CYP3A4 . .

AccessionsENST00000373910.9
A0A087WW00
P51668
ENST00000615793.1