SARS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	28 studies	24% ± 11%	Explore
natural killer cell	23 studies	19% ± 3%	Explore
pericyte	23 studies	24% ± 7%	Explore
endothelial cell	22 studies	26% ± 11%	Explore
smooth muscle cell	18 studies	24% ± 8%	Explore
CD8-positive, alpha-beta T cell	14 studies	19% ± 3%	Explore
regulatory T cell	14 studies	20% ± 3%	Explore
basal cell	12 studies	28% ± 9%	Explore
CD4-positive, alpha-beta T cell	12 studies	19% ± 4%	Explore
myofibroblast cell	12 studies	25% ± 8%	Explore
connective tissue cell	11 studies	23% ± 5%	Explore
B cell	10 studies	18% ± 4%	Explore
epithelial cell	10 studies	35% ± 16%	Explore
T cell	9 studies	19% ± 4%	Explore
endothelial cell of lymphatic vessel	9 studies	23% ± 8%	Explore
type II pneumocyte	9 studies	27% ± 16%	Explore
capillary endothelial cell	9 studies	20% ± 4%	Explore
gamma-delta T cell	9 studies	23% ± 11%	Explore
plasma cell	8 studies	30% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	20% ± 3%	Explore
mature NK T cell	8 studies	18% ± 2%	Explore
endothelial cell of vascular tree	8 studies	21% ± 5%	Explore
classical monocyte	7 studies	21% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	22% ± 3%	Explore
non-classical monocyte	7 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	20% ± 3%	Explore
neuron	7 studies	35% ± 14%	Explore
macrophage	7 studies	22% ± 7%	Explore
memory B cell	7 studies	18% ± 3%	Explore
naive B cell	6 studies	20% ± 4%	Explore
vein endothelial cell	6 studies	20% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	22% ± 6%	Explore
secretory cell	6 studies	21% ± 4%	Explore
mast cell	5 studies	19% ± 1%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	20% ± 2%	Explore
conventional dendritic cell	5 studies	29% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	21% ± 2%	Explore
endothelial cell of artery	5 studies	20% ± 4%	Explore
ciliated cell	5 studies	30% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	22% ± 5%	Explore
oligodendrocyte	5 studies	23% ± 6%	Explore
type I pneumocyte	4 studies	27% ± 8%	Explore
retinal ganglion cell	4 studies	70% ± 28%	Explore
precursor B cell	4 studies	24% ± 7%	Explore
amacrine cell	4 studies	40% ± 15%	Explore
astrocyte	4 studies	29% ± 9%	Explore
retina horizontal cell	4 studies	41% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	20% ± 4%	Explore
abnormal cell	4 studies	24% ± 9%	Explore
oligodendrocyte precursor cell	4 studies	28% ± 7%	Explore
enteroendocrine cell	4 studies	27% ± 14%	Explore
mucosal invariant T cell	4 studies	20% ± 3%	Explore
GABAergic neuron	4 studies	32% ± 16%	Explore
interneuron	4 studies	34% ± 19%	Explore
plasmacytoid dendritic cell	4 studies	22% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	20% ± 5%	Explore
pancreatic A cell	3 studies	50% ± 10%	Explore
type B pancreatic cell	3 studies	45% ± 7%	Explore
kidney loop of Henle epithelial cell	3 studies	23% ± 2%	Explore
extravillous trophoblast	3 studies	33% ± 11%	Explore
placental villous trophoblast	3 studies	47% ± 10%	Explore
club cell	3 studies	29% ± 12%	Explore
Mueller cell	3 studies	22% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	21% ± 2%	Explore
muscle cell	3 studies	30% ± 17%	Explore
goblet cell	3 studies	22% ± 5%	Explore
intestinal crypt stem cell	3 studies	21% ± 4%	Explore
T follicular helper cell	3 studies	16% ± 1%	Explore
transit amplifying cell	3 studies	26% ± 8%	Explore
glutamatergic neuron	3 studies	43% ± 18%	Explore
double negative thymocyte	3 studies	27% ± 12%	Explore
hepatocyte	3 studies	32% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	10 studies	24% ± 6%	Explore
peripheral blood	10 studies	21% ± 3%	Explore
eye	7 studies	25% ± 9%	Explore
brain	5 studies	30% ± 10%	Explore
uterus	4 studies	25% ± 11%	Explore
intestine	4 studies	23% ± 10%	Explore
pancreas	3 studies	43% ± 14%	Explore
kidney	3 studies	18% ± 1%	Explore
placenta	3 studies	30% ± 5%	Explore
lymph node	3 studies	19% ± 4%	Explore
liver	3 studies	32% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	8824.25	1445 / 1445	100%	89.24	183 / 183
lung	100%	11439.33	578 / 578	100%	108.59	1155 / 1155
ovary	100%	7389.03	180 / 180	100%	100.29	430 / 430
pancreas	100%	7803.08	328 / 328	100%	115.58	178 / 178
prostate	100%	7430.69	245 / 245	100%	125.14	502 / 502
skin	100%	12357.11	1809 / 1809	100%	160.76	472 / 472
stomach	100%	8370.07	359 / 359	100%	107.45	286 / 286
thymus	100%	9394.53	653 / 653	100%	178.76	604 / 605
breast	100%	8903.78	459 / 459	100%	133.85	1116 / 1118
intestine	100%	8382.74	966 / 966	100%	126.13	526 / 527
uterus	100%	8331.72	170 / 170	100%	130.09	458 / 459
kidney	100%	6027.35	89 / 89	100%	105.94	898 / 901
brain	100%	7780.05	2629 / 2642	100%	160.31	705 / 705
liver	100%	5310.86	225 / 226	100%	95.02	405 / 406
bladder	100%	9101.14	21 / 21	99%	119.60	500 / 504
adrenal gland	100%	8366.88	258 / 258	97%	109.36	224 / 230
adipose	100%	8598.32	1204 / 1204	0%	0	0 / 0
blood vessel	100%	9816.45	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	129.87	80 / 80
lymph node	0%	0	0 / 0	100%	116.17	29 / 29
spleen	100%	6729.81	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	128.38	45 / 45
ureter	0%	0	0 / 0	100%	54.50	1 / 1
muscle	100%	6077.55	801 / 803	0%	0	0 / 0
peripheral blood	97%	5223.84	903 / 929	0%	0	0 / 0
heart	97%	5979.71	832 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006412	Biological process	translation
GO_0001514	Biological process	selenocysteine incorporation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0016525	Biological process	negative regulation of angiogenesis
GO_0006400	Biological process	tRNA modification
GO_0006434	Biological process	seryl-tRNA aminoacylation
GO_1904046	Biological process	negative regulation of vascular endothelial growth factor production
GO_0002181	Biological process	cytoplasmic translation
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0005524	Molecular function	ATP binding
GO_0004828	Molecular function	serine-tRNA ligase activity
GO_0000049	Molecular function	tRNA binding
GO_0005515	Molecular function	protein binding
GO_0098619	Molecular function	selenocysteine-tRNA ligase activity

IV. Literature review

[source]

Gene name	SARS1
Protein name	Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (Seryl-tRNA(Ser/Sec) synthetase)
Synonyms	SERS SARS
Description	FUNCTION: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) . Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) . In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC . Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA . .
Accessions	ENST00000234677.7 Q0VGA5 ENST00000369923.4 P49591 Q5T5C7

SARS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review