CXXC5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	26 studies	29% ± 12%	Explore
naive B cell	17 studies	24% ± 7%	Explore
memory B cell	16 studies	30% ± 10%	Explore
plasmacytoid dendritic cell	16 studies	38% ± 11%	Explore
natural killer cell	15 studies	22% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	29% ± 7%	Explore
oligodendrocyte	10 studies	26% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	27% ± 10%	Explore
glutamatergic neuron	9 studies	26% ± 14%	Explore
abnormal cell	7 studies	38% ± 20%	Explore
neuron	7 studies	31% ± 16%	Explore
endothelial cell	7 studies	27% ± 10%	Explore
retina horizontal cell	7 studies	56% ± 25%	Explore
precursor B cell	7 studies	41% ± 13%	Explore
pericyte	6 studies	19% ± 5%	Explore
immature B cell	6 studies	49% ± 19%	Explore
plasma cell	5 studies	30% ± 13%	Explore
plasmablast	5 studies	47% ± 6%	Explore
kidney loop of Henle epithelial cell	5 studies	24% ± 8%	Explore
astrocyte	5 studies	28% ± 11%	Explore
pro-B cell	5 studies	34% ± 15%	Explore
epithelial cell	5 studies	38% ± 16%	Explore
ciliated cell	5 studies	29% ± 10%	Explore
innate lymphoid cell	5 studies	26% ± 4%	Explore
endothelial cell of lymphatic vessel	4 studies	19% ± 3%	Explore
hematopoietic precursor cell	4 studies	33% ± 14%	Explore
squamous epithelial cell	4 studies	31% ± 20%	Explore
mature NK T cell	4 studies	27% ± 8%	Explore
connective tissue cell	4 studies	29% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	40% ± 7%	Explore
gamma-delta T cell	4 studies	24% ± 8%	Explore
amacrine cell	4 studies	41% ± 17%	Explore
brush cell	4 studies	32% ± 11%	Explore
Mueller cell	4 studies	23% ± 3%	Explore
fibroblast	4 studies	24% ± 3%	Explore
goblet cell	4 studies	30% ± 9%	Explore
interneuron	4 studies	37% ± 24%	Explore
ionocyte	3 studies	31% ± 1%	Explore
classical monocyte	3 studies	23% ± 8%	Explore
neural crest cell	3 studies	23% ± 1%	Explore
retinal bipolar neuron	3 studies	36% ± 4%	Explore
glial cell	3 studies	32% ± 18%	Explore
glycinergic amacrine cell	3 studies	30% ± 8%	Explore
retinal ganglion cell	3 studies	50% ± 23%	Explore
basal cell	3 studies	29% ± 7%	Explore
retinal cone cell	3 studies	31% ± 10%	Explore
OFF-bipolar cell	3 studies	24% ± 10%	Explore
germinal center B cell	3 studies	24% ± 3%	Explore
dendritic cell	3 studies	38% ± 23%	Explore
hematopoietic stem cell	3 studies	30% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	29% ± 10%	Explore
hepatocyte	3 studies	34% ± 21%	Explore
oligodendrocyte precursor cell	3 studies	29% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	23% ± 9%	Explore
eye	7 studies	22% ± 7%	Explore
pancreas	3 studies	28% ± 9%	Explore
peripheral blood	3 studies	26% ± 10%	Explore
kidney	3 studies	19% ± 3%	Explore
lung	3 studies	24% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	6104.09	89 / 89	100%	96.63	898 / 901
liver	100%	5477.15	226 / 226	100%	83.69	404 / 406
brain	100%	6546.50	2631 / 2642	100%	146.24	704 / 705
pancreas	100%	3861.83	328 / 328	99%	75.90	177 / 178
thymus	100%	2788.79	652 / 653	99%	121.95	600 / 605
prostate	99%	1895.82	242 / 245	99%	49.03	495 / 502
intestine	99%	2029.89	957 / 966	96%	69.99	506 / 527
breast	100%	2526.21	459 / 459	94%	110.49	1053 / 1118
skin	100%	2616.73	1806 / 1809	93%	80.74	438 / 472
stomach	100%	1881.49	359 / 359	92%	60.18	264 / 286
adrenal gland	99%	2236.88	256 / 258	90%	88.79	207 / 230
bladder	100%	1680.62	21 / 21	81%	48.59	409 / 504
lung	99%	1841.00	571 / 578	76%	35.26	879 / 1155
uterus	88%	1575.86	150 / 170	85%	67.50	391 / 459
esophagus	96%	2001.03	1392 / 1445	69%	28.01	126 / 183
ovary	22%	297.78	39 / 180	100%	158.04	429 / 430
spleen	100%	3901.18	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	39.40	1 / 1
blood vessel	100%	4106.19	1334 / 1335	0%	0	0 / 0
adipose	99%	2501.98	1192 / 1204	0%	0	0 / 0
muscle	98%	2977.59	789 / 803	0%	0	0 / 0
heart	97%	2109.16	835 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	77.63	26 / 29
tonsil	0%	0	0 / 0	78%	29.62	35 / 45
peripheral blood	58%	1477.15	540 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	35%	10.14	28 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043467	Biological process	regulation of generation of precursor metabolites and energy
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0008327	Molecular function	methyl-CpG binding
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0008270	Molecular function	zinc ion binding
GO_0043565	Molecular function	sequence-specific DNA binding

IV. Literature review

[source]

Gene name	CXXC5
Protein name	CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF) CXXC finger protein 5
Synonyms	TCCCIA00297 HSPC195
Description	FUNCTION: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) . May repress COX4I2 transactivation induced by CHCHD2 and RBPJ . Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG . .
Accessions	ENST00000502295.1 ENST00000507139.5 Q7LFL8 D6RHC6 ENST00000520967.1 ENST00000504944.1 ENST00000509238.1 ENST00000511457.1 ENST00000511048.1 [Q7LFL8-1] D6RCN9 D6RHG9 ENST00000502336.5 E7EV55 ENST00000302517.8 [Q7LFL8-1] D6R9V1 A0A1D5RMR5 ENST00000512816.1 D6RJC1 D6R966 D6RDY2 E7EVI8 ENST00000511591.1 D6RIR8 ENST00000502716.1 D6RBE0 ENST00000503511.1 ENST00000504844.1

CXXC5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review