ZNF750 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZNF750 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZNF750 at tissue level.

III. Associated gene sets

GO_0010628Biological processpositive regulation of gene expression
GO_2000304Biological processpositive regulation of ceramide biosynthetic process
GO_0044091Biological processmembrane biogenesis
GO_0008544Biological processepidermis development
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0030154Biological processcell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0061436Biological processestablishment of skin barrier
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNF750
Protein nameZinc finger protein 750
Synonyms
DescriptionFUNCTION: Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression. .

AccessionsI3L0W7
ENST00000572562.1
Q32MQ0
ENST00000269394.4