TRIM29 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1900181Biological processnegative regulation of protein localization to nucleus
GO_0098609Biological processcell-cell adhesion
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045087Biological processinnate immune response
GO_0005764Cellular componentlysosome
GO_0005912Cellular componentadherens junction
GO_0098641Molecular functioncadherin binding involved in cell-cell adhesion
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0002039Molecular functionp53 binding

IV. Literature review

[source]
Gene nameTRIM29
Protein nameTripartite motif containing 29
Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein)
TRIM29 protein
SynonymsATDC
DescriptionFUNCTION: Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. .

AccessionsH0YD78
E9PIQ2
E9PRL4
ENST00000532833.1
ENST00000475051.4
ENST00000529011.1
H0YF27
ENST00000533302.5
E9PJ94
ENST00000341846.10 [Q14134-1]
ENST00000529040.1
ENST00000531555.5
Q0P6H7
E9PM74
E9PI31
ENST00000627238.1
ENST00000529495.1
E9PPX1
ENST00000526881.1
ENST00000528870.5
E9PJD4
E9PLI4
ENST00000529044.5
Q14134