MAGEA2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MAGEA2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAGEA2 at tissue level.

III. Associated gene sets

GO_0072331Biological processsignal transduction by p53 class mediator
GO_0090398Biological processcellular senescence
GO_0051443Biological processpositive regulation of ubiquitin-protein transferase activity
GO_0033234Biological processnegative regulation of protein sumoylation
GO_1901984Biological processnegative regulation of protein acetylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0030163Biological processprotein catabolic process
GO_0016605Cellular componentPML body
GO_0005634Cellular componentnucleus
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameMAGEA2
Protein nameMelanoma-associated antigen 2 (Cancer/testis antigen 1.2) (CT1.2) (MAGE-2 antigen)
MAGE family member A2
MAGEA2 protein
SynonymsMAGEA2B
MAGEA2A;
MAGE2
DescriptionFUNCTION: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation. .

AccessionsENST00000370293.6
ENST00000458057.5
ENST00000709976.1
ENST00000623806.3
ENST00000611674.4
ENST00000684311.1
ENST00000611557.4
ENST00000682532.1
ENST00000709981.1
ENST00000623438.3
ENST00000331220.6
ENST00000598543.5
ENST00000709978.1
A0A087WZT8
E7ENJ0
Q2VPA5
ENST00000617505.1
P43356
ENST00000595583.5
ENST00000617846.4
ENST00000620710.4