PHF21A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0000118Cellular componenthistone deacetylase complex
GO_0005654Cellular componentnucleoplasm
GO_1990391Cellular componentDNA repair complex
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene namePHF21A
Protein namePHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)
PHD finger protein 21A
SynonymsBM-006
BHC80
KIAA1696
DescriptionFUNCTION: Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. .

AccessionsENST00000524497.5
ENST00000532010.5
ENST00000531959.5
ENST00000533757.5
H0YCI1
Q96BD5
ENST00000693049.1
ENST00000690620.1 [Q96BD5-2]
E9PLU5
H0YEK2
E9PR02
A0A1B0GX09
ENST00000418153.6 [Q96BD5-1]
E9PNN4
ENST00000530587.6
E9PNW9
ENST00000323180.10 [Q96BD5-2]
A0A1D5RMU1
E9PLV4
ENST00000529734.5
ENST00000676320.1 [Q96BD5-3]
ENST00000532028.1
H0YCM5
ENST00000525438.5
ENST00000529782.5
ENST00000527782.5
ENST00000532883.5
E9PQM3
ENST00000525676.6
E9PS51