ID4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
smooth muscle cell	26 studies	43% ± 18%	Explore
fibroblast	22 studies	25% ± 8%	Explore
pericyte	22 studies	41% ± 15%	Explore
astrocyte	19 studies	44% ± 18%	Explore
mesothelial cell	9 studies	50% ± 25%	Explore
connective tissue cell	8 studies	25% ± 9%	Explore
type I pneumocyte	7 studies	26% ± 9%	Explore
myofibroblast cell	7 studies	35% ± 18%	Explore
epithelial cell	5 studies	42% ± 24%	Explore
ciliated cell	5 studies	40% ± 25%	Explore
GABAergic neuron	4 studies	20% ± 6%	Explore
abnormal cell	4 studies	38% ± 5%	Explore
Mueller cell	4 studies	39% ± 11%	Explore
neuron	4 studies	29% ± 18%	Explore
type II pneumocyte	3 studies	26% ± 8%	Explore
pancreatic A cell	3 studies	41% ± 11%	Explore
club cell	3 studies	22% ± 7%	Explore
basal cell	3 studies	32% ± 8%	Explore
adipocyte	3 studies	26% ± 13%	Explore
myoepithelial cell	3 studies	47% ± 10%	Explore
ependymal cell	3 studies	48% ± 16%	Explore
melanocyte	3 studies	28% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	4 studies	20% ± 5%	Explore
uterus	4 studies	31% ± 15%	Explore
pancreas	3 studies	36% ± 10%	Explore
eye	3 studies	21% ± 5%	Explore
intestine	3 studies	19% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	21439.43	652 / 653	89%	282.63	539 / 605
brain	86%	3896.86	2269 / 2642	99%	421.46	698 / 705
ovary	84%	5522.91	152 / 180	90%	164.08	389 / 430
breast	97%	5139.48	443 / 459	30%	24.49	330 / 1118
bladder	95%	3703.00	20 / 21	26%	21.08	129 / 504
kidney	55%	1602.71	49 / 89	64%	58.27	581 / 901
skin	72%	8363.16	1307 / 1809	39%	25.70	186 / 472
prostate	76%	2526.49	187 / 245	35%	16.31	174 / 502
uterus	83%	3665.55	141 / 170	27%	20.26	126 / 459
lung	89%	3287.98	515 / 578	21%	11.10	238 / 1155
esophagus	88%	3126.20	1266 / 1445	13%	6.59	23 / 183
blood vessel	100%	16641.71	1335 / 1335	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	42.43	1 / 1
adipose	99%	7118.26	1189 / 1204	0%	0	0 / 0
stomach	61%	1402.90	218 / 359	9%	3.44	26 / 286
heart	49%	3375.00	419 / 861	0%	0	0 / 0
spleen	44%	1016.05	106 / 241	0%	0	0 / 0
pancreas	17%	347.55	55 / 328	19%	6.57	34 / 178
intestine	24%	567.24	234 / 966	11%	4.32	60 / 527
tonsil	0%	0	0 / 0	18%	7.26	8 / 45
adrenal gland	6%	150.34	16 / 258	9%	5.47	20 / 230
eye	0%	0	0 / 0	11%	5.12	9 / 80
liver	1%	17.89	2 / 226	4%	1.90	15 / 406
muscle	1%	30.37	9 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002052	Biological process	positive regulation of neuroblast proliferation
GO_0048715	Biological process	negative regulation of oligodendrocyte differentiation
GO_0021766	Biological process	hippocampus development
GO_0045444	Biological process	fat cell differentiation
GO_0001649	Biological process	osteoblast differentiation
GO_0010628	Biological process	positive regulation of gene expression
GO_0045599	Biological process	negative regulation of fat cell differentiation
GO_0048712	Biological process	negative regulation of astrocyte differentiation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0048708	Biological process	astrocyte differentiation
GO_0022010	Biological process	central nervous system myelination
GO_0032922	Biological process	circadian regulation of gene expression
GO_0045665	Biological process	negative regulation of neuron differentiation
GO_0060741	Biological process	prostate gland stromal morphogenesis
GO_0060740	Biological process	prostate gland epithelium morphogenesis
GO_0030154	Biological process	cell differentiation
GO_0061682	Biological process	seminal vesicle morphogenesis
GO_0008104	Biological process	protein localization
GO_0021895	Biological process	cerebral cortex neuron differentiation
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0000082	Biological process	G1/S transition of mitotic cell cycle
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0007405	Biological process	neuroblast proliferation
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0140416	Molecular function	transcription regulator inhibitor activity
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0140110	Molecular function	transcription regulator activity
GO_0046983	Molecular function	protein dimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ID4
Protein name	DNA-binding protein inhibitor ID-4 (Class B basic helix-loop-helix protein 27) (bHLHb27) (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4)
Synonyms	BHLHB27
Description	FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). .
Accessions	P47928 ENST00000378700.8

ID4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review