BHLHE41 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010944Biological processnegative regulation of transcription by competitive promoter binding
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032922Biological processcircadian regulation of gene expression
GO_0010832Biological processnegative regulation of myotube differentiation
GO_0009952Biological processanterior/posterior pattern specification
GO_0050767Biological processregulation of neurogenesis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043425Molecular functionbHLH transcription factor binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0070888Molecular functionE-box binding
GO_0043426Molecular functionMRF binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameBHLHE41
Protein nameBasic helix-loop-helix family, member e41 (Basic helix-loop-helix protein 3 isoform 1)
Class E basic helix-loop-helix protein 41 (bHLHe41) (Class B basic helix-loop-helix protein 3) (bHLHb3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1)
SynonymsBHLHB3
SHARP1
DEC2
DescriptionFUNCTION: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes . Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes . Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11 (By similarity). .

AccessionsENST00000242728.5
Q8TAT1
Q9C0J9