POLE3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	15 studies	22% ± 6%	Explore
CD4-positive, alpha-beta T cell	9 studies	20% ± 4%	Explore
plasmacytoid dendritic cell	9 studies	21% ± 7%	Explore
naive B cell	8 studies	18% ± 3%	Explore
B cell	8 studies	21% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	20% ± 3%	Explore
CD8-positive, alpha-beta T cell	8 studies	21% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	19% ± 2%	Explore
mucosal invariant T cell	7 studies	18% ± 3%	Explore
gamma-delta T cell	7 studies	24% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	19% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	19% ± 2%	Explore
regulatory T cell	6 studies	18% ± 3%	Explore
plasmablast	5 studies	35% ± 14%	Explore
erythroblast	5 studies	39% ± 15%	Explore
pro-B cell	5 studies	30% ± 13%	Explore
epithelial cell	5 studies	34% ± 15%	Explore
memory B cell	5 studies	18% ± 1%	Explore
classical monocyte	4 studies	21% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	22% ± 4%	Explore
non-classical monocyte	4 studies	24% ± 8%	Explore
conventional dendritic cell	4 studies	31% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 3%	Explore
hematopoietic precursor cell	4 studies	33% ± 5%	Explore
precursor B cell	4 studies	26% ± 6%	Explore
endothelial cell	4 studies	24% ± 7%	Explore
dendritic cell	4 studies	34% ± 14%	Explore
T cell	3 studies	19% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	23% ± 3%	Explore
mature NK T cell	3 studies	19% ± 2%	Explore
common myeloid progenitor	3 studies	22% ± 5%	Explore
ciliated cell	3 studies	37% ± 4%	Explore
basal cell	3 studies	32% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 5%	Explore
granulocyte monocyte progenitor cell	3 studies	27% ± 8%	Explore
intestinal crypt stem cell	3 studies	18% ± 1%	Explore
erythrocyte	3 studies	39% ± 16%	Explore
double negative thymocyte	3 studies	29% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	7 studies	21% ± 5%	Explore
lung	5 studies	21% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	2544.64	459 / 459	100%	108.74	1118 / 1118
esophagus	100%	2867.83	1445 / 1445	100%	93.10	183 / 183
intestine	100%	2751.38	966 / 966	100%	103.26	527 / 527
lung	100%	2383.23	578 / 578	100%	100.31	1155 / 1155
ovary	100%	1907.87	180 / 180	100%	97.50	430 / 430
stomach	100%	2022.65	359 / 359	100%	85.40	286 / 286
uterus	100%	2311.54	170 / 170	100%	126.29	459 / 459
thymus	100%	2011.73	653 / 653	100%	69.34	602 / 605
brain	100%	2243.13	2632 / 2642	100%	95.63	704 / 705
bladder	100%	2531.57	21 / 21	99%	93.17	501 / 504
prostate	100%	2190.30	245 / 245	99%	72.98	499 / 502
skin	100%	3770.99	1809 / 1809	99%	83.15	469 / 472
pancreas	99%	1548.81	326 / 328	99%	61.85	176 / 178
liver	99%	1502.43	224 / 226	98%	44.64	399 / 406
kidney	100%	1729.35	89 / 89	97%	57.20	876 / 901
adrenal gland	100%	3158.31	258 / 258	97%	55.66	222 / 230
adipose	100%	2524.75	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2633.37	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	121.19	29 / 29
muscle	100%	3814.64	803 / 803	0%	0	0 / 0
spleen	100%	3350.25	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	151.66	45 / 45
ureter	0%	0	0 / 0	100%	62.13	1 / 1
heart	97%	1411.91	832 / 861	0%	0	0 / 0
peripheral blood	96%	2314.72	895 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	94%	36.58	75 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006974	Biological process	DNA damage response
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006260	Biological process	DNA replication
GO_0006338	Biological process	chromatin remodeling
GO_0006261	Biological process	DNA-templated DNA replication
GO_0031507	Biological process	heterochromatin formation
GO_0006334	Biological process	nucleosome assembly
GO_0071897	Biological process	DNA biosynthetic process
GO_0006272	Biological process	leading strand elongation
GO_0006275	Biological process	regulation of DNA replication
GO_0008623	Cellular component	CHRAC
GO_0005654	Cellular component	nucleoplasm
GO_0005721	Cellular component	pericentric heterochromatin
GO_0140672	Cellular component	ATAC complex
GO_0008622	Cellular component	epsilon DNA polymerase complex
GO_0005634	Cellular component	nucleus
GO_0003887	Molecular function	DNA-directed DNA polymerase activity
GO_0046982	Molecular function	protein heterodimerization activity
GO_0031490	Molecular function	chromatin DNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	POLE3
Protein name	DNA polymerase epsilon subunit 3 (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17)
Synonyms	CHRAC17
Description	FUNCTION: Accessory component of the DNA polymerase epsilon complex . Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 . Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex . .
Accessions	ENST00000374171.5 Q9NRF9 ENST00000374169.7

POLE3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review