NKX6-1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NKX6-1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NKX6-1 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0048715Biological processnegative regulation of oligodendrocyte differentiation
GO_0007224Biological processsmoothened signaling pathway
GO_0030516Biological processregulation of axon extension
GO_0031016Biological processpancreas development
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_2001222Biological processregulation of neuron migration
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0009887Biological processanimal organ morphogenesis
GO_0021953Biological processcentral nervous system neuron differentiation
GO_0003310Biological processpancreatic A cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032024Biological processpositive regulation of insulin secretion
GO_0072560Biological processtype B pancreatic cell maturation
GO_2000078Biological processpositive regulation of type B pancreatic cell development
GO_0071345Biological processcellular response to cytokine stimulus
GO_0030154Biological processcell differentiation
GO_0071375Biological processcellular response to peptide hormone stimulus
GO_0048714Biological processpositive regulation of oligodendrocyte differentiation
GO_0035094Biological processresponse to nicotine
GO_0048709Biological processoligodendrocyte differentiation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0044342Biological processtype B pancreatic cell proliferation
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0010255Biological processglucose mediated signaling pathway
GO_0070062Cellular componentextracellular exosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameNKX6-1
Protein nameNK6 homeobox 1
Homeobox protein Nkx-6.1 (Homeobox protein NK-6 homolog A)
SynonymsNKX6A
DescriptionFUNCTION: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). .

AccessionsF8VWZ9
P78426
ENST00000515820.6
ENST00000295886.5