SKI | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	16 studies	28% ± 13%	Explore
microglial cell	11 studies	40% ± 15%	Explore
fibroblast	11 studies	22% ± 5%	Explore
astrocyte	9 studies	26% ± 10%	Explore
macrophage	9 studies	26% ± 12%	Explore
adipocyte	8 studies	33% ± 7%	Explore
glutamatergic neuron	6 studies	38% ± 18%	Explore
epithelial cell	6 studies	26% ± 10%	Explore
GABAergic neuron	6 studies	32% ± 15%	Explore
endothelial cell of lymphatic vessel	5 studies	20% ± 4%	Explore
smooth muscle cell	5 studies	20% ± 2%	Explore
neuron	4 studies	21% ± 8%	Explore
oligodendrocyte precursor cell	4 studies	34% ± 13%	Explore
lymphocyte	4 studies	28% ± 11%	Explore
endothelial cell of artery	4 studies	18% ± 2%	Explore
monocyte	4 studies	19% ± 3%	Explore
pericyte	4 studies	23% ± 8%	Explore
interneuron	4 studies	42% ± 18%	Explore
oligodendrocyte	4 studies	25% ± 8%	Explore
T cell	3 studies	27% ± 13%	Explore
dendritic cell	3 studies	19% ± 5%	Explore
myeloid cell	3 studies	23% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	20% ± 1%	Explore
muscle cell	3 studies	22% ± 8%	Explore
alveolar macrophage	3 studies	30% ± 11%	Explore
mast cell	3 studies	21% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	10 studies	30% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9471.37	1445 / 1445	100%	76.87	183 / 183
prostate	100%	8073.99	245 / 245	100%	53.92	502 / 502
skin	100%	9403.87	1809 / 1809	100%	71.55	472 / 472
ovary	100%	9832.76	180 / 180	100%	78.14	429 / 430
thymus	100%	7808.08	652 / 653	100%	51.68	602 / 605
breast	100%	9372.26	459 / 459	99%	54.54	1110 / 1118
intestine	100%	8067.51	965 / 966	99%	46.31	523 / 527
lung	100%	9740.65	577 / 578	99%	53.40	1143 / 1155
uterus	100%	12012.73	170 / 170	98%	46.21	452 / 459
bladder	100%	8779.62	21 / 21	98%	39.77	495 / 504
stomach	99%	5257.89	354 / 359	99%	55.47	284 / 286
brain	98%	9469.66	2590 / 2642	100%	71.80	703 / 705
kidney	98%	4270.08	87 / 89	95%	43.98	860 / 901
adrenal gland	100%	3855.03	258 / 258	88%	25.19	203 / 230
liver	99%	3542.46	224 / 226	87%	21.22	354 / 406
pancreas	69%	1714.22	225 / 328	98%	47.33	174 / 178
adipose	100%	10549.06	1204 / 1204	0%	0	0 / 0
blood vessel	100%	18168.96	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	50.19	80 / 80
spleen	100%	6474.83	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	46.23	45 / 45
ureter	0%	0	0 / 0	100%	19.57	1 / 1
heart	99%	5545.74	851 / 861	0%	0	0 / 0
muscle	97%	3488.50	776 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	66%	16.16	19 / 29
peripheral blood	63%	1844.51	582 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0048870	Biological process	cell motility
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0009948	Biological process	anterior/posterior axis specification
GO_0060349	Biological process	bone morphogenesis
GO_0060392	Biological process	negative regulation of SMAD protein signal transduction
GO_0048147	Biological process	negative regulation of fibroblast proliferation
GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_0043585	Biological process	nose morphogenesis
GO_0048593	Biological process	camera-type eye morphogenesis
GO_0048741	Biological process	skeletal muscle fiber development
GO_0014902	Biological process	myotube differentiation
GO_0060041	Biological process	retina development in camera-type eye
GO_0010626	Biological process	negative regulation of Schwann cell proliferation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0032926	Biological process	negative regulation of activin receptor signaling pathway
GO_0021772	Biological process	olfactory bulb development
GO_0022011	Biological process	myelination in peripheral nervous system
GO_0060038	Biological process	cardiac muscle cell proliferation
GO_0060021	Biological process	roof of mouth development
GO_0030326	Biological process	embryonic limb morphogenesis
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0001843	Biological process	neural tube closure
GO_0043388	Biological process	positive regulation of DNA binding
GO_0043010	Biological process	camera-type eye development
GO_0002089	Biological process	lens morphogenesis in camera-type eye
GO_0060325	Biological process	face morphogenesis
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0005813	Cellular component	centrosome
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0017053	Cellular component	transcription repressor complex
GO_0016604	Cellular component	nuclear body
GO_0016605	Cellular component	PML body
GO_0005737	Cellular component	cytoplasm
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0019904	Molecular function	protein domain specific binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0019901	Molecular function	protein kinase binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0042802	Molecular function	identical protein binding
GO_0046332	Molecular function	SMAD binding
GO_0008270	Molecular function	zinc ion binding
GO_0046811	Molecular function	histone deacetylase inhibitor activity
GO_0005515	Molecular function	protein binding

Gene name	SKI
Protein name	Ski oncoprotein Ski oncogene (Proto-oncogene c-Ski)
Synonyms
Description	FUNCTION: May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. .
Accessions	Q7Z459 Q7Z462 Q7Z461 P12755 ENST00000378536.5

SKI report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review