EHMT2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EHMT2 at tissue level.

III. Associated gene sets

GO_0035265Biological processorgan growth
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0031399Biological processregulation of protein modification process
GO_0007130Biological processsynaptonemal complex assembly
GO_0007616Biological processlong-term memory
GO_0006346Biological processDNA methylation-dependent heterochromatin formation
GO_0048665Biological processneuron fate specification
GO_0044027Biological processnegative regulation of gene expression via chromosomal CpG island methylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0009267Biological processcellular response to starvation
GO_0045471Biological processresponse to ethanol
GO_0048599Biological processoocyte development
GO_0009566Biological processfertilization
GO_0071314Biological processcellular response to cocaine
GO_0060992Biological processresponse to fungicide
GO_1902902Biological processnegative regulation of autophagosome assembly
GO_0018027Biological processpeptidyl-lysine dimethylation
GO_0036166Biological processphenotypic switching
GO_0048148Biological processbehavioral response to cocaine
GO_0006275Biological processregulation of DNA replication
GO_0007286Biological processspermatid development
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0046974Molecular functionhistone H3K9 methyltransferase activity
GO_0001222Molecular functiontranscription corepressor binding
GO_0046976Molecular functionhistone H3K27 methyltransferase activity
GO_0140759Molecular functionhistone H3K56 methyltransferase activity
GO_0140947Molecular functionhistone H3K9me2 methyltransferase activity
GO_0008270Molecular functionzinc ion binding
GO_0016279Molecular functionprotein-lysine N-methyltransferase activity
GO_0002039Molecular functionp53 binding
GO_0005515Molecular functionprotein binding
GO_0070742Molecular functionC2H2 zinc finger domain binding

IV. Literature review

[source]
Gene nameEHMT2
Protein nameHistone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)
Histone-lysine N-methyltransferase EHMT2
Euchromatic histone lysine methyltransferase 2 (Histone-lysine N-methyltransferase EHMT2)
SynonymsKMT1C
NG36
BAT8
G9A
C6orf30
DescriptionFUNCTION: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. Recruited to the promoters of target genes through interaction with transcriptional repressor MSX1, leading to the inhibition of myoblast differentiation via transcriptional repression of differentiation factors (By similarity). .

AccessionsENST00000629838.2
ENST00000448415.1
ENST00000451745.5
ENST00000424396.1
ENST00000420336.6
A2ABF9
ENST00000447162.1
ENST00000421926.6
ENST00000425250.6
Q96KQ7
ENST00000375528.8
ENST00000400008.7
ENST00000436403.6
H0Y4K5
A0A0G2JRN8
ENST00000458593.5
ENST00000427405.6
ENST00000436026.1
ENST00000454705.5
ENST00000383372.6 [Q96KQ7-2]
ENST00000440987.5
ENST00000375537.9 [Q96KQ7-1]
A0A0G2JRR0
ENST00000627114.2
ENST00000400006.7
A2ABF8
ENST00000450323.6
ENST00000420874.5 [Q96KQ7-2]
ENST00000429506.6 [Q96KQ7-1]
ENST00000443951.6
ENST00000446303.6
ENST00000450075.6 [Q96KQ7-1]
ENST00000420930.2
ENST00000420623.1
A0A0G2JIS2
A0A0G2JK64
ENST00000375530.8 [Q96KQ7-2]
ENST00000415323.6
ENST00000428442.6
ENST00000450229.5 [Q96KQ7-2]
A0A0G2JIR1
ENST00000395728.7
ENST00000383373.8 [Q96KQ7-1]
ENST00000419454.1