DNMT3L report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DNMT3L at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DNMT3L at tissue level.

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0141005Biological processretrotransposon silencing by heterochromatin formation
GO_0060718Biological processchorionic trophoblast cell differentiation
GO_0007283Biological processspermatogenesis
GO_0032259Biological processmethylation
GO_0141068Biological processautosome genomic imprinting
GO_0006346Biological processDNA methylation-dependent heterochromatin formation
GO_0044726Biological processepigenetic programing of female pronucleus
GO_0071514Biological processgenomic imprinting
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0001890Biological processplacenta development
GO_0007141Biological processmale meiosis I
GO_0090310Biological processnegative regulation of DNA methylation-dependent heterochromatin formation
GO_0048863Biological processstem cell differentiation
GO_1902494Cellular componentcatalytic complex
GO_0000792Cellular componentheterochromatin
GO_0035098Cellular componentESC/E(Z) complex
GO_0005829Cellular componentcytosol
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0008047Molecular functionenzyme activator activity
GO_0051718Molecular functionDNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDNMT3L
Protein nameDNA (cytosine-5)-methyltransferase 3-like
DNA methyltransferase 3 like
Synonyms
DescriptionFUNCTION: Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain . Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases . Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 . Plays a key role in embryonic stem cells and germ cells (By similarity). In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity). Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (By similarity). While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity). Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity). .

AccessionsC9J0T5
Q9UJW3
ENST00000628202.3 [Q9UJW3-1]
ENST00000431166.1
ENST00000270172.7 [Q9UJW3-2]