SOX15 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SOX15 at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070318Biological processpositive regulation of G0 to G1 transition
GO_0043403Biological processskeletal muscle tissue regeneration
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0014718Biological processpositive regulation of satellite cell activation involved in skeletal muscle regeneration
GO_2000288Biological processpositive regulation of myoblast proliferation
GO_0060707Biological processtrophoblast giant cell differentiation
GO_0030182Biological processneuron differentiation
GO_0030154Biological processcell differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0045843Biological processnegative regulation of striated muscle tissue development
GO_0007420Biological processbrain development
GO_0008584Biological processmale gonad development
GO_0048627Biological processmyoblast development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSOX15
Protein nameProtein SOX-15 (Protein SOX-12) (Protein SOX-20)
SynonymsSOX27
SOX20
SOX26
SOX12
DescriptionFUNCTION: Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity). Acts as a transcriptional activator and repressor (By similarity). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity). Regulates transcription of HRC via binding to it proximal enhancer region (By similarity). Involved in skeletal muscle regeneration (By similarity). Also plays a role in the development of myogenic precursor cells (By similarity). .

AccessionsENST00000250055.3 [O60248-1]
O60248
ENST00000570788.1 [O60248-2]
ENST00000538513.6 [O60248-1]