PRDM16 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050873Biological processbrown fat cell differentiation
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0032259Biological processmethylation
GO_0043457Biological processregulation of cellular respiration
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0070828Biological processheterochromatin organization
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0005829Cellular componentcytosol
GO_0016235Cellular componentaggresome
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0046974Molecular functionhistone H3K9 methyltransferase activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0140947Molecular functionhistone H3K9me2 methyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0140938Molecular functionhistone H3 methyltransferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0140948Molecular functionhistone H3K9 monomethyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRDM16
Protein namePR/SET domain 16
Alternative protein PRDM16
Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)
SynonymsMEL1
KIAA1675
PFM13
DescriptionFUNCTION: Binds DNA and functions as a transcriptional regulator . Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling . .; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator . Functions as a repressor of TGF-beta signaling . May regulate granulocyte differentiation . .

AccessionsENST00000378391.6 [Q9HAZ2-2]
D6RDW0
ENST00000463591.1
D6RFY3
ENST00000509860.1
L8E8P9
U3KQL6
ENST00000511072.5
Q9HAZ2
H0YA13
ENST00000270722.10 [Q9HAZ2-1]
ENST00000514189.5