Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 39 studies | 55% ± 15% | |
| smooth muscle cell | 26 studies | 43% ± 17% | |
| endothelial cell | 6 studies | 35% ± 6% | |
| fibroblast | 5 studies | 29% ± 19% | |
| epithelial cell | 4 studies | 26% ± 9% | |
| basal cell | 3 studies | 29% ± 8% | |
| club cell | 3 studies | 18% ± 4% |
Insufficient scRNA-seq data for expression of NOTCH3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 21977.70 | 459 / 459 | 98% | 99.16 | 1098 / 1118 |
| esophagus | 96% | 16175.56 | 1393 / 1445 | 100% | 214.97 | 183 / 183 |
| lung | 99% | 15684.59 | 572 / 578 | 95% | 107.13 | 1102 / 1155 |
| uterus | 99% | 17918.64 | 169 / 170 | 95% | 107.89 | 435 / 459 |
| thymus | 99% | 14635.46 | 648 / 653 | 93% | 60.06 | 564 / 605 |
| bladder | 95% | 10545.76 | 20 / 21 | 91% | 80.12 | 460 / 504 |
| prostate | 93% | 9663.22 | 227 / 245 | 75% | 28.46 | 378 / 502 |
| skin | 91% | 24214.65 | 1639 / 1809 | 64% | 32.45 | 303 / 472 |
| ovary | 56% | 6834.79 | 100 / 180 | 97% | 115.61 | 415 / 430 |
| kidney | 67% | 5796.88 | 60 / 89 | 68% | 81.25 | 610 / 901 |
| intestine | 60% | 5336.58 | 581 / 966 | 72% | 38.82 | 380 / 527 |
| stomach | 35% | 2777.75 | 126 / 359 | 82% | 58.96 | 234 / 286 |
| pancreas | 10% | 606.14 | 34 / 328 | 95% | 67.14 | 169 / 178 |
| brain | 24% | 1285.50 | 624 / 2642 | 81% | 35.70 | 572 / 705 |
| blood vessel | 100% | 60179.43 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 87.09 | 1 / 1 |
| adipose | 100% | 29117.24 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 135.92 | 44 / 45 |
| heart | 87% | 8150.66 | 751 / 861 | 0% | 0 | 0 / 0 |
| spleen | 77% | 5527.28 | 185 / 241 | 0% | 0 | 0 / 0 |
| muscle | 74% | 5557.33 | 598 / 803 | 0% | 0 | 0 / 0 |
| adrenal gland | 11% | 554.68 | 28 / 258 | 61% | 35.80 | 140 / 230 |
| liver | 1% | 60.72 | 3 / 226 | 34% | 15.00 | 139 / 406 |
| eye | 0% | 0 | 0 / 0 | 25% | 6.73 | 20 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 4.78 | 4 / 29 |
| peripheral blood | 0% | 10.83 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0048844 | Biological process | artery morphogenesis |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0048663 | Biological process | neuron fate commitment |
| GO_0030900 | Biological process | forebrain development |
| GO_0048661 | Biological process | positive regulation of smooth muscle cell proliferation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0072104 | Biological process | glomerular capillary formation |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_0014016 | Biological process | neuroblast differentiation |
| GO_0007411 | Biological process | axon guidance |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0009986 | Cellular component | cell surface |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NOTCH3 |
| Protein name | Notch 3-like protein Notch receptor 3 Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] |
| Synonyms | |
| Description | FUNCTION: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination . Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). . |
| Accessions | M0QZN3 ENST00000595514.1 ENST00000597756.1 Q9UM47 B8XFT4 M0R3C9 M0QX38 ENST00000601011.1 ENST00000263388.7 |
