PTPN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042532Biological processnegative regulation of tyrosine phosphorylation of STAT protein
GO_0060334Biological processregulation of type II interferon-mediated signaling pathway
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0070104Biological processnegative regulation of interleukin-6-mediated signaling pathway
GO_0046426Biological processnegative regulation of receptor signaling pathway via JAK-STAT
GO_0042059Biological processnegative regulation of epidermal growth factor receptor signaling pathway
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0038020Biological processinsulin receptor recycling
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0060336Biological processnegative regulation of type II interferon-mediated signaling pathway
GO_0035335Biological processpeptidyl-tyrosine dephosphorylation
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1902202Biological processregulation of hepatocyte growth factor receptor signaling pathway
GO_1902206Biological processnegative regulation of interleukin-2-mediated signaling pathway
GO_1902215Biological processnegative regulation of interleukin-4-mediated signaling pathway
GO_0050922Biological processnegative regulation of chemotaxis
GO_0030217Biological processT cell differentiation
GO_0030218Biological processerythrocyte differentiation
GO_0045722Biological processpositive regulation of gluconeogenesis
GO_1902237Biological processpositive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0045650Biological processnegative regulation of macrophage differentiation
GO_0050728Biological processnegative regulation of inflammatory response
GO_0008286Biological processinsulin receptor signaling pathway
GO_1903899Biological processpositive regulation of PERK-mediated unfolded protein response
GO_1902233Biological processnegative regulation of positive thymic T cell selection
GO_1902227Biological processnegative regulation of macrophage colony-stimulating factor signaling pathway
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0010888Biological processnegative regulation of lipid storage
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0030183Biological processB cell differentiation
GO_0042593Biological processglucose homeostasis
GO_2000587Biological processnegative regulation of platelet-derived growth factor receptor-beta signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0031904Cellular componentendosome lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0005737Cellular componentcytoplasm
GO_0004726Molecular functionnon-membrane spanning protein tyrosine phosphatase activity
GO_0019901Molecular functionprotein kinase binding
GO_0097677Molecular functionSTAT family protein binding
GO_0005178Molecular functionintegrin binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0019905Molecular functionsyntaxin binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTPN2
Protein nameProtein tyrosine phosphatase non-receptor type 2
Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48)
protein-tyrosine-phosphatase (EC 3.1.3.48)
Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP)
SynonymshCG_1999834
PTPT
PTN2
DescriptionFUNCTION: Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA. .

AccessionsENST00000591305.5
ENST00000585666.5
ENST00000645816.1
K7EIY0
D3DUJ3
ENST00000309660.10 [P17706-1]
ENST00000589216.1
ENST00000327283.7 [P17706-2]
A8K3N4
ENST00000587703.5
ENST00000592776.1
ENST00000591115.5 [P17706-4]
K7ERU1
K7EIE9
P17706
ENST00000592059.5
ENST00000591901.5
ENST00000591497.5
ENST00000646492.1
K7ENP9
K7EQG9
K7ELS9
A0A2R8YD79
ENST00000645191.1
K7ER87
ENST00000353319.8 [P17706-3]