KDM5A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0032922Biological processcircadian regulation of gene expression
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0140718Biological processfacultative heterochromatin formation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0051090Biological processregulation of DNA-binding transcription factor activity
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0003677Molecular functionDNA binding
GO_0004857Molecular functionenzyme inhibitor activity
GO_0042393Molecular functionhistone binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0034647Molecular functionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity
GO_0032452Molecular functionhistone demethylase activity
GO_0008270Molecular functionzinc ion binding
GO_0031490Molecular functionchromatin DNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKDM5A
Protein nameLysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A)
Lysine-specific demethylase 5A
Lysine demethylase 5A
SynonymsJARID1A
RBP2
RBBP2
DescriptionFUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif . May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation . May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells . .

AccessionsF5GZR8
ENST00000543507.1
ENST00000536014.5
ENST00000544760.1
ENST00000399788.7 [P29375-1]
P29375
F5H322
E7EV89
F5GZ99
A0A6B9SM32
ENST00000535014.5