ACVR2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0035265Biological processorgan growth
GO_0007498Biological processmesoderm development
GO_0032924Biological processactivin receptor signaling pathway
GO_0060841Biological processvenous blood vessel development
GO_0007178Biological processcell surface receptor protein serine/threonine kinase signaling pathway
GO_0030324Biological processlung development
GO_0001974Biological processblood vessel remodeling
GO_0009791Biological processpost-embryonic development
GO_0009749Biological processresponse to glucose
GO_0031016Biological processpancreas development
GO_0060836Biological processlymphatic endothelial cell differentiation
GO_0007507Biological processheart development
GO_0007368Biological processdetermination of left/right symmetry
GO_0007165Biological processsignal transduction
GO_0001822Biological processkidney development
GO_0001946Biological processlymphangiogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032927Biological processpositive regulation of activin receptor signaling pathway
GO_0071363Biological processcellular response to growth factor stimulus
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0061298Biological processretina vasculature development in camera-type eye
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0030509Biological processBMP signaling pathway
GO_0060021Biological processroof of mouth development
GO_0006355Biological processregulation of DNA-templated transcription
GO_0009952Biological processanterior/posterior pattern specification
GO_0030073Biological processinsulin secretion
GO_0060840Biological processartery development
GO_0006468Biological processprotein phosphorylation
GO_0030501Biological processpositive regulation of bone mineralization
GO_0048617Biological processembryonic foregut morphogenesis
GO_0048705Biological processskeletal system morphogenesis
GO_0001702Biological processgastrulation with mouth forming second
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005737Cellular componentcytoplasm
GO_0048179Cellular componentactivin receptor complex
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0048185Molecular functionactivin binding
GO_0019209Molecular functionkinase activator activity
GO_0017002Molecular functionactivin receptor activity
GO_0019838Molecular functiongrowth factor binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0016362Molecular functionactivin receptor activity, type II
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameACVR2B
Protein nameSerine/threonine-protein kinase receptor (EC 2.7.11.30)
Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)
Synonyms
DescriptionFUNCTION: Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. .

AccessionsQ13705
ENST00000352511.5 [Q13705-1]
Q4VAU9