MXD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070443Cellular componentMad-Max complex
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameMXD1
Protein nameMax dimerization protein 1 (Max dimerizer 1) (Protein MAD)
MAX dimerization protein 1
MXD1 protein
SynonymsMAD
DescriptionFUNCTION: Component of a transcriptional repressor complex together with MAX . In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' . Antagonizes MYC transcriptional activity by competing with MYC for MAX binding . Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding . .

AccessionsF8WBI0
ENST00000435990.5
C9JBE8
B7ZLI7
ENST00000540449.5 [Q05195-2]
ENST00000409442.2
ENST00000264444.7 [Q05195-1]
Q05195