MAX | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	26 studies	22% ± 6%	Explore
CD4-positive, alpha-beta T cell	22 studies	25% ± 9%	Explore
endothelial cell	21 studies	27% ± 9%	Explore
regulatory T cell	19 studies	29% ± 8%	Explore
CD8-positive, alpha-beta T cell	18 studies	26% ± 7%	Explore
B cell	16 studies	25% ± 5%	Explore
memory B cell	16 studies	21% ± 4%	Explore
T cell	14 studies	23% ± 5%	Explore
naive B cell	14 studies	23% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	27% ± 7%	Explore
fibroblast	14 studies	22% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	26% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	23% ± 7%	Explore
macrophage	13 studies	29% ± 12%	Explore
mature NK T cell	12 studies	24% ± 8%	Explore
monocyte	12 studies	19% ± 4%	Explore
smooth muscle cell	12 studies	18% ± 2%	Explore
gamma-delta T cell	12 studies	27% ± 9%	Explore
platelet	11 studies	52% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	28% ± 6%	Explore
endothelial cell of lymphatic vessel	11 studies	24% ± 7%	Explore
mucosal invariant T cell	10 studies	26% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 7%	Explore
pericyte	10 studies	18% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	26% ± 7%	Explore
dendritic cell	9 studies	26% ± 15%	Explore
mast cell	9 studies	21% ± 6%	Explore
astrocyte	9 studies	29% ± 13%	Explore
classical monocyte	8 studies	27% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	26% ± 6%	Explore
microglial cell	8 studies	27% ± 13%	Explore
myeloid cell	8 studies	22% ± 6%	Explore
endothelial cell of vascular tree	8 studies	21% ± 8%	Explore
glutamatergic neuron	7 studies	38% ± 21%	Explore
adipocyte	7 studies	24% ± 5%	Explore
plasmacytoid dendritic cell	7 studies	23% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	20% ± 3%	Explore
conventional dendritic cell	6 studies	28% ± 11%	Explore
megakaryocyte	6 studies	76% ± 19%	Explore
hematopoietic stem cell	6 studies	34% ± 25%	Explore
myofibroblast cell	6 studies	22% ± 7%	Explore
epithelial cell	6 studies	37% ± 15%	Explore
T follicular helper cell	6 studies	25% ± 7%	Explore
oligodendrocyte	6 studies	30% ± 8%	Explore
precursor B cell	5 studies	26% ± 10%	Explore
cardiac muscle cell	5 studies	22% ± 5%	Explore
GABAergic neuron	5 studies	38% ± 15%	Explore
basal cell	5 studies	28% ± 11%	Explore
hematopoietic precursor cell	4 studies	32% ± 15%	Explore
leukocyte	4 studies	24% ± 4%	Explore
non-classical monocyte	4 studies	31% ± 7%	Explore
exhausted T cell	4 studies	26% ± 7%	Explore
endothelial cell of artery	4 studies	18% ± 1%	Explore
lymphocyte	4 studies	26% ± 8%	Explore
capillary endothelial cell	4 studies	18% ± 1%	Explore
immature B cell	4 studies	24% ± 4%	Explore
retina horizontal cell	4 studies	19% ± 2%	Explore
mononuclear phagocyte	4 studies	23% ± 10%	Explore
ciliated cell	4 studies	26% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	25% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	30% ± 8%	Explore
innate lymphoid cell	4 studies	24% ± 4%	Explore
oligodendrocyte precursor cell	4 studies	29% ± 9%	Explore
goblet cell	4 studies	32% ± 18%	Explore
interneuron	4 studies	38% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	21% ± 5%	Explore
abnormal cell	4 studies	26% ± 9%	Explore
pro-B cell	3 studies	28% ± 8%	Explore
amacrine cell	3 studies	22% ± 6%	Explore
retinal cone cell	3 studies	21% ± 2%	Explore
vein endothelial cell	3 studies	25% ± 12%	Explore
Mueller cell	3 studies	18% ± 2%	Explore
muscle cell	3 studies	31% ± 5%	Explore
type I pneumocyte	3 studies	20% ± 3%	Explore
type II pneumocyte	3 studies	21% ± 5%	Explore
granulocyte	3 studies	31% ± 17%	Explore
enterocyte	3 studies	19% ± 1%	Explore
club cell	3 studies	23% ± 2%	Explore
respiratory goblet cell	3 studies	23% ± 7%	Explore
alveolar macrophage	3 studies	22% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 4%	Explore
brush cell	3 studies	26% ± 7%	Explore
neuron	3 studies	37% ± 10%	Explore
double negative thymocyte	3 studies	36% ± 10%	Explore
connective tissue cell	3 studies	19% ± 1%	Explore
erythrocyte	3 studies	25% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	25% ± 7%	Explore
brain	10 studies	31% ± 17%	Explore
lung	6 studies	20% ± 3%	Explore
bone marrow	4 studies	20% ± 3%	Explore
heart	4 studies	18% ± 2%	Explore
lymph node	4 studies	22% ± 5%	Explore
adipose	4 studies	20% ± 3%	Explore
intestine	3 studies	21% ± 7%	Explore
liver	3 studies	28% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5226.64	1445 / 1445	100%	20.54	183 / 183
intestine	100%	4753.11	966 / 966	100%	27.08	527 / 527
kidney	100%	3350.67	89 / 89	100%	26.35	901 / 901
ovary	100%	5166.65	180 / 180	100%	24.30	430 / 430
prostate	100%	5581.21	245 / 245	100%	32.54	502 / 502
stomach	100%	3099.36	359 / 359	100%	22.82	286 / 286
thymus	100%	4581.98	653 / 653	100%	42.31	605 / 605
uterus	100%	5808.99	170 / 170	100%	36.23	459 / 459
skin	100%	4477.70	1808 / 1809	100%	38.90	472 / 472
breast	100%	4138.51	459 / 459	100%	36.81	1117 / 1118
lung	100%	5342.74	577 / 578	100%	28.94	1155 / 1155
brain	100%	3757.29	2637 / 2642	100%	32.28	705 / 705
bladder	100%	4904.29	21 / 21	100%	27.46	503 / 504
adrenal gland	100%	3193.71	258 / 258	100%	24.89	229 / 230
pancreas	99%	1630.50	324 / 328	99%	31.02	177 / 178
liver	100%	1911.56	226 / 226	98%	13.51	398 / 406
adipose	100%	4377.31	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	47.78	80 / 80
lymph node	0%	0	0 / 0	100%	46.82	29 / 29
spleen	100%	6966.57	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	36.07	45 / 45
ureter	0%	0	0 / 0	100%	13.92	1 / 1
blood vessel	100%	3481.03	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	6237.79	928 / 929	0%	0	0 / 0
heart	100%	2916.45	859 / 861	0%	0	0 / 0
muscle	99%	2705.69	798 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0032993	Cellular component	protein-DNA complex
GO_0071339	Cellular component	MLL1 complex
GO_0070443	Cellular component	Mad-Max complex
GO_0005654	Cellular component	nucleoplasm
GO_0030425	Cellular component	dendrite
GO_0090575	Cellular component	RNA polymerase II transcription regulator complex
GO_0000785	Cellular component	chromatin
GO_0071943	Cellular component	Myc-Max complex
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0000977	Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0042802	Molecular function	identical protein binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0070888	Molecular function	E-box binding
GO_0046983	Molecular function	protein dimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MAX
Protein name	Protein max (Myc-associated factor X) Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) MYC associated factor X
Synonyms	BHLHD4 hCG_41671
Description	FUNCTION: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. .
Accessions	ENST00000557746.5 ENST00000394606.6 [P61244-3] ENST00000555932.5 G3V563 Q6V3B1 ENST00000555667.5 G3V570 ENST00000553928.5 [P61244-3] ENST00000358664.9 [P61244-1] ENST00000246163.2 [P61244-5] ENST00000557277.5 ENST00000651648.1 ENST00000556443.5 ENST00000284165.10 [P61244-4] ENST00000556892.6 A0A494C130 ENST00000556979.6 [P61244-3] ENST00000555419.5 G3V2N4 Q8IYC6 P61244 Q8TAX8 ENST00000341653.6 [P61244-6] G3V2R5 ENST00000358402.8 [P61244-2] G3V302 G3V5L1

MAX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review