E2F8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of E2F8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of E2F8 at tissue level.

III. Associated gene sets

GO_0032466Biological processnegative regulation of cytokinesis
GO_0060718Biological processchorionic trophoblast cell differentiation
GO_0032877Biological processpositive regulation of DNA endoreduplication
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0001890Biological processplacenta development
GO_0060707Biological processtrophoblast giant cell differentiation
GO_0002040Biological processsprouting angiogenesis
GO_0048144Biological processfibroblast proliferation
GO_0070365Biological processhepatocyte differentiation
GO_0033301Biological processcell cycle comprising mitosis without cytokinesis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001217Molecular functionDNA-binding transcription repressor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameE2F8
Protein nameE2F transcription factor 8
Transcription factor E2F8 (E2F-8)
Synonyms
DescriptionFUNCTION: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. .

AccessionsENST00000527884.5
A0AVK6
ENST00000532666.1
E9PMT9
ENST00000250024.9
ENST00000620009.4