BCL11A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_1903860Biological processnegative regulation of dendrite extension
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1904800Biological processnegative regulation of neuron remodeling
GO_1905232Biological processcellular response to L-glutamate
GO_2000173Biological processnegative regulation of branching morphogenesis of a nerve
GO_2000171Biological processnegative regulation of dendrite development
GO_0016514Cellular componentSWI/SNF complex
GO_0005654Cellular componentnucleoplasm
GO_0098794Cellular componentpostsynapse
GO_0016363Cellular componentnuclear matrix
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0019901Molecular functionprotein kinase binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameBCL11A
Protein nameB-cell CLL/lymphoma 11A (Zinc finger protein), isoform CRA_b (BCL11A B-cell CLL/lymphoma 11A (Zinc finger protein) isoform 1)
B-cell lymphoma/leukemia 11A (BCL-11A) (B-cell CLL/lymphoma 11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856)
B-cell CLL/lymphoma 11A (Zinc finger protein), isoform CRA_d (BCL11 transcription factor A)
B-cell CLL/lymphoma 11A (Zinc finger protein) isoform 2 (B-cell CLL/lymphoma 11A (Zinc finger protein), isoform CRA_c)
BCL11 transcription factor A
BCL11a-M
Uncharacterized protein BCL11A
SynonymsKIAA1809
CTIP1
ZNF856
EVI9
hCG_1986387
DescriptionFUNCTION: Transcription factor . Associated with the BAF SWI/SNF chromatin remodeling complex . Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene . Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level . Involved in brain development . May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). .

AccessionsENST00000643716.1
A0A2R8YCR5
ENST00000356842.9 [Q9H165-2]
ENST00000642439.1
A0A2R8YHH4
ENST00000643459.1
A0A2R8YDW6
ENST00000335712.11 [Q9H165-6]
A0A2R8Y7B0
ENST00000642384.2 [Q9H165-1]
ENST00000647472.1
A0A0J9YYJ9
ENST00000647469.1
I3PG23
A0A2U3TZJ5
ENST00000358510.6
ENST00000643222.1
ENST00000489516.7
ENST00000409351.5 [Q9H165-8]
ENST00000643004.1
ENST00000646249.1
D9YZV9
A0A0J9YY13
ENST00000631857.1
A0A2R8YDS7
D9YZW0
ENST00000489183.1
A0A2R8Y7W4
A0A0J9YXG2
ENST00000479026.2
Q9H165
A0A2R8YEK1
Q53TS1
ENST00000642180.1
A0A2R8YGT9
A0A2R8Y2E8
ENST00000359629.10 [Q9H165-3]
Q53TE8