FOXD3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FOXD3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FOXD3 at tissue level.

III. Associated gene sets

GO_0030154Biological processcell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0001701Biological processin utero embryonic development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0009653Biological processanatomical structure morphogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameFOXD3
Protein nameForkhead box protein D3 (HNF3/FH transcription factor genesis)
SynonymsHFH2
DescriptionFUNCTION: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor . Also acts as a transcriptional activator . Negatively regulates transcription of transcriptional repressor RHIT/ZNF205 . Promotes development of neural crest cells from neural tube progenitors . Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation . Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis . .

AccessionsQ9UJU5
ENST00000371116.4