CIITA report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CIITA at tissue level.

III. Associated gene sets

GO_0045348Biological processpositive regulation of MHC class II biosynthetic process
GO_0032966Biological processnegative regulation of collagen biosynthetic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045345Biological processpositive regulation of MHC class I biosynthetic process
GO_0046597Biological processnegative regulation of viral entry into host cell
GO_0034341Biological processresponse to type II interferon
GO_0006955Biological processimmune response
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0046677Biological processresponse to antibiotic
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0003677Molecular functionDNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0016746Molecular functionacyltransferase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005525Molecular functionGTP binding
GO_0005524Molecular functionATP binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCIITA
Protein nameClass II transactivator
MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1)
Class II MHC mutant RJ2.2.5 (Class II major histocompatibility complex transactivator)
Class II major histocompatibility complex transactivator
SynonymsMHC2TA
DescriptionFUNCTION: Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter . Does not bind DNA . May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, . Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter . Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription . Exhibits intrinsic GTP-stimulated acetyltransferase activity . Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) . Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 . Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion . .; FUNCTION: [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression. .

AccessionsA0A2R8YFU9
ENST00000324288.14
ENST00000381835.9 [P33076-3]
ENST00000644232.1
ENST00000646979.1
A0A1B0GU01
ENST00000618207.4
ENST00000636238.1
A0A2R8Y7F5
ENST00000576601.1
P33076
Q29704
A0A087X2I7
I3L2P7
Q6LC19
I3L2E5
A0A1B0GUQ8
ENST00000571186.5
ENST00000618327.4
A0A0B4J1S1
ENST00000637439.1