HCFC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010628Biological processpositive regulation of gene expression
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0019046Biological processrelease from viral latency
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0050821Biological processprotein stabilization
GO_0006355Biological processregulation of DNA-templated transcription
GO_0043254Biological processregulation of protein-containing complex assembly
GO_0045787Biological processpositive regulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035097Cellular componenthistone methyltransferase complex
GO_0044545Cellular componentNSL complex
GO_0071339Cellular componentMLL1 complex
GO_0016020Cellular componentmembrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0044665Cellular componentMLL1/2 complex
GO_0005737Cellular componentcytoplasm
GO_0048188Cellular componentSet1C/COMPASS complex
GO_0000123Cellular componenthistone acetyltransferase complex
GO_0005634Cellular componentnucleus
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0003682Molecular functionchromatin binding
GO_0045296Molecular functioncadherin binding
GO_0042802Molecular functionidentical protein binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHCFC1
Protein nameHost cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
Host cell factor C1
HCFC1 protein
SynonymsHFC1
HCF1
DescriptionFUNCTION: Transcriptional coregulator (By similarity). Involved in control of the cell cycle . Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 . Coactivator for EGR2 and GABP2 . Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together . Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 . As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues . Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition . Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). .; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. .

AccessionsENST00000444191.5
P51610
ENST00000369984.4
Q05C05
H7C1C4
ENST00000310441.12 [P51610-1]
A6NEM2