CDX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009790Biological processembryo development
GO_0009948Biological processanterior/posterior axis specification
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0009887Biological processanimal organ morphogenesis
GO_0001829Biological processtrophectodermal cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045597Biological processpositive regulation of cell differentiation
GO_0060711Biological processlabyrinthine layer development
GO_0030154Biological processcell differentiation
GO_0008333Biological processendosome to lysosome transport
GO_0001568Biological processblood vessel development
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0048863Biological processstem cell differentiation
GO_0060575Biological processintestinal epithelial cell differentiation
GO_0014807Biological processregulation of somitogenesis
GO_0045197Biological processestablishment or maintenance of epithelial cell apical/basal polarity
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035019Biological processsomatic stem cell population maintenance
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0008327Molecular functionmethyl-CpG binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCDX2
Protein nameHomeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2)
CDX2/AS
Homeobox protein miniCDX2 variant
SynonymsCDX3
DescriptionFUNCTION: Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA . .

AccessionsQ99626
ENST00000381020.8
A0A0M3L9V7
A0A076MKN9