JUN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034614Biological processcellular response to reactive oxygen species
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0043922Biological processnegative regulation by host of viral transcription
GO_0071276Biological processcellular response to cadmium ion
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0019046Biological processrelease from viral latency
GO_0060395Biological processSMAD protein signal transduction
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043923Biological processpositive regulation by host of viral transcription
GO_2000144Biological processpositive regulation of DNA-templated transcription initiation
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0043392Biological processnegative regulation of DNA binding
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0042127Biological processregulation of cell population proliferation
GO_0051726Biological processregulation of cell cycle
GO_0140467Biological processintegrated stress response signaling
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000228Cellular componentnuclear chromosome
GO_0035976Cellular componenttranscription factor AP-1 complex
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0070412Molecular functionR-SMAD binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005096Molecular functionGTPase activator activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0140296Molecular functiongeneral transcription initiation factor binding
GO_0003723Molecular functionRNA binding
GO_0044389Molecular functionubiquitin-like protein ligase binding
GO_0035497Molecular functioncAMP response element binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameJUN
Protein nameTranscription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
Transcription factor Jun (Activator protein 1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog)
Synonyms
DescriptionFUNCTION: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' . Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway . Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation . Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells . Binds to the USP28 promoter in colorectal cancer (CRC) cells . .; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. .

AccessionsA0AA34QVR9
ENST00000371222.4
ENST00000710273.1
ENST00000678696.1
P05412
Q6FHK0