BIN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	28 studies	30% ± 10%	Explore
CD4-positive, alpha-beta T cell	27 studies	31% ± 12%	Explore
CD8-positive, alpha-beta T cell	25 studies	32% ± 12%	Explore
B cell	24 studies	28% ± 11%	Explore
regulatory T cell	20 studies	34% ± 12%	Explore
mature NK T cell	18 studies	30% ± 10%	Explore
oligodendrocyte	17 studies	48% ± 17%	Explore
T cell	16 studies	27% ± 8%	Explore
memory B cell	15 studies	28% ± 6%	Explore
microglial cell	15 studies	44% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	30% ± 11%	Explore
macrophage	14 studies	32% ± 15%	Explore
gamma-delta T cell	14 studies	33% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	32% ± 11%	Explore
fibroblast	13 studies	27% ± 8%	Explore
naive B cell	13 studies	27% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	32% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	36% ± 10%	Explore
conventional dendritic cell	11 studies	25% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	31% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	34% ± 13%	Explore
plasmacytoid dendritic cell	9 studies	27% ± 11%	Explore
mucosal invariant T cell	8 studies	32% ± 4%	Explore
dendritic cell	7 studies	34% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	35% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	33% ± 9%	Explore
epithelial cell of proximal tubule	6 studies	27% ± 7%	Explore
connective tissue cell	6 studies	24% ± 8%	Explore
GABAergic neuron	6 studies	36% ± 18%	Explore
glutamatergic neuron	6 studies	42% ± 22%	Explore
T follicular helper cell	6 studies	23% ± 8%	Explore
leukocyte	5 studies	29% ± 10%	Explore
neuron	5 studies	38% ± 18%	Explore
retinal rod cell	5 studies	23% ± 5%	Explore
epithelial cell	5 studies	33% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	41% ± 12%	Explore
exhausted T cell	4 studies	44% ± 17%	Explore
endothelial cell	4 studies	36% ± 8%	Explore
myofibroblast cell	4 studies	22% ± 5%	Explore
retinal cone cell	4 studies	36% ± 10%	Explore
myeloid cell	4 studies	30% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	49% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	30% ± 9%	Explore
astrocyte	3 studies	20% ± 3%	Explore
neural crest cell	3 studies	17% ± 2%	Explore
pericyte	3 studies	22% ± 3%	Explore
retinal bipolar neuron	3 studies	39% ± 7%	Explore
OFF-bipolar cell	3 studies	23% ± 7%	Explore
immature B cell	3 studies	37% ± 7%	Explore
intraepithelial lymphocyte	3 studies	27% ± 5%	Explore
rod bipolar cell	3 studies	31% ± 10%	Explore
abnormal cell	3 studies	23% ± 3%	Explore
innate lymphoid cell	3 studies	32% ± 8%	Explore
T-helper 1 cell	3 studies	31% ± 12%	Explore
T-helper 17 cell	3 studies	20% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	35% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	26% ± 10%	Explore
double negative thymocyte	3 studies	38% ± 1%	Explore
interneuron	3 studies	33% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	27% ± 6%	Explore
brain	13 studies	40% ± 18%	Explore
kidney	5 studies	22% ± 3%	Explore
eye	5 studies	23% ± 7%	Explore
lymph node	4 studies	24% ± 4%	Explore
lung	3 studies	23% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	13471.59	2641 / 2642	100%	95.24	705 / 705
prostate	100%	6617.28	244 / 245	99%	34.19	495 / 502
adrenal gland	100%	9163.24	258 / 258	97%	70.31	224 / 230
thymus	98%	3361.47	640 / 653	99%	24.59	596 / 605
intestine	97%	3528.16	941 / 966	98%	35.89	515 / 527
stomach	99%	3900.39	355 / 359	96%	32.59	275 / 286
kidney	100%	7470.06	89 / 89	93%	61.21	837 / 901
ovary	99%	3606.65	179 / 180	91%	23.66	391 / 430
uterus	98%	5157.09	167 / 170	81%	35.18	372 / 459
lung	92%	2482.97	531 / 578	85%	19.49	987 / 1155
bladder	100%	9722.38	21 / 21	63%	17.67	319 / 504
liver	64%	1413.70	145 / 226	95%	25.53	385 / 406
breast	98%	4057.93	450 / 459	50%	8.28	564 / 1118
esophagus	70%	2708.12	1018 / 1445	75%	18.97	138 / 183
skin	49%	1482.66	879 / 1809	73%	20.25	346 / 472
pancreas	21%	407.80	68 / 328	94%	28.12	168 / 178
muscle	100%	96947.57	803 / 803	0%	0	0 / 0
spleen	100%	5971.81	241 / 241	0%	0	0 / 0
adipose	99%	4722.99	1196 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	44.32	28 / 29
eye	0%	0	0 / 0	95%	23.68	76 / 80
tonsil	0%	0	0 / 0	91%	19.42	41 / 45
peripheral blood	67%	2537.71	627 / 929	0%	0	0 / 0
blood vessel	48%	1215.82	644 / 1335	0%	0	0 / 0
heart	9%	164.46	76 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0045664	Biological process	regulation of neuron differentiation
GO_1903946	Biological process	negative regulation of ventricular cardiac muscle cell action potential
GO_0030838	Biological process	positive regulation of actin filament polymerization
GO_0006897	Biological process	endocytosis
GO_1901380	Biological process	negative regulation of potassium ion transmembrane transport
GO_0048488	Biological process	synaptic vesicle endocytosis
GO_1902430	Biological process	negative regulation of amyloid-beta formation
GO_0048711	Biological process	positive regulation of astrocyte differentiation
GO_0051647	Biological process	nucleus localization
GO_1902960	Biological process	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO_0045807	Biological process	positive regulation of endocytosis
GO_0007010	Biological process	cytoskeleton organization
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_1904878	Biological process	negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO_0006997	Biological process	nucleus organization
GO_0010564	Biological process	regulation of cell cycle process
GO_0008333	Biological process	endosome to lysosome transport
GO_0033292	Biological process	T-tubule organization
GO_0086091	Biological process	regulation of heart rate by cardiac conduction
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0060988	Biological process	lipid tube assembly
GO_0098978	Cellular component	glutamatergic synapse
GO_0005856	Cellular component	cytoskeleton
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0030018	Cellular component	Z disc
GO_0043679	Cellular component	axon terminus
GO_0043194	Cellular component	axon initial segment
GO_0005635	Cellular component	nuclear envelope
GO_0030425	Cellular component	dendrite
GO_0043196	Cellular component	varicosity
GO_0030315	Cellular component	T-tubule
GO_0015629	Cellular component	actin cytoskeleton
GO_0090571	Cellular component	RNA polymerase II transcription repressor complex
GO_0031674	Cellular component	I band
GO_0044300	Cellular component	cerebellar mossy fiber
GO_0005829	Cellular component	cytosol
GO_0008021	Cellular component	synaptic vesicle
GO_0098850	Cellular component	extrinsic component of synaptic vesicle membrane
GO_0005737	Cellular component	cytoplasm
GO_0033268	Cellular component	node of Ranvier
GO_0030424	Cellular component	axon
GO_0005768	Cellular component	endosome
GO_0060987	Cellular component	lipid tube
GO_0031982	Cellular component	vesicle
GO_0005634	Cellular component	nucleus
GO_0070063	Molecular function	RNA polymerase binding
GO_0005543	Molecular function	phospholipid binding
GO_0051020	Molecular function	GTPase binding
GO_0051015	Molecular function	actin filament binding
GO_0042802	Molecular function	identical protein binding
GO_0019828	Molecular function	aspartic-type endopeptidase inhibitor activity
GO_0002020	Molecular function	protease binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0048156	Molecular function	tau protein binding
GO_0030276	Molecular function	clathrin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	BIN1
Protein name	Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1) Bridging integrator 1
Synonyms	AMPHL
Description	FUNCTION: Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling . Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production . In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation . Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro . .
Accessions	ENST00000348750.8 [O00499-9] O00499 ENST00000316724.10 [O00499-1] ENST00000352848.8 [O00499-8] ENST00000376113.6 [O00499-10] ENST00000351659.7 [O00499-3] ENST00000357970.7 [O00499-5] ENST00000393041.7 [O00499-4] ENST00000409400.1 [O00499-7] ENST00000346226.7 [O00499-2] Q9BTH3 ENST00000259238.8 [O00499-11] ENST00000393040.7 [O00499-6]

BIN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review