TMPRSS6 | OmnibusX

Name	Number of supported studies	Average coverage
hepatocyte	4 studies	35% ± 18%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TMPRSS6 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	9446.89	226 / 226	97%	133.08	392 / 406
lung	93%	106.26	539 / 578	29%	5.05	331 / 1155
thymus	39%	22.01	253 / 653	62%	39.70	375 / 605
stomach	83%	74.03	297 / 359	9%	0.49	25 / 286
pancreas	51%	29.40	168 / 328	39%	5.44	70 / 178
ovary	44%	18.42	80 / 180	38%	3.42	163 / 430
intestine	69%	35.74	662 / 966	13%	0.69	71 / 527
spleen	76%	45.73	183 / 241	0%	0	0 / 0
skin	75%	153.67	1355 / 1809	1%	0.03	4 / 472
breast	19%	12.89	88 / 459	53%	8.01	590 / 1118
prostate	67%	35.66	163 / 245	1%	0.02	3 / 502
uterus	56%	27.52	95 / 170	8%	0.57	35 / 459
bladder	43%	18.81	9 / 21	8%	1.04	39 / 504
peripheral blood	50%	55.72	468 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	48%	4.66	14 / 29
esophagus	35%	15.11	512 / 1445	7%	0.48	13 / 183
brain	34%	144.71	907 / 2642	0%	0.06	3 / 705
blood vessel	26%	10.71	345 / 1335	0%	0	0 / 0
kidney	12%	6.82	11 / 89	12%	0.60	110 / 901
adrenal gland	16%	6.95	41 / 258	3%	0.10	6 / 230
adipose	9%	4.05	103 / 1204	0%	0	0 / 0
heart	4%	1.76	38 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.10	1 / 45
muscle	0%	0.12	2 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0030509	Biological process	BMP signaling pathway
GO_0022617	Biological process	extracellular matrix disassembly
GO_0060586	Biological process	multicellular organismal-level iron ion homeostasis
GO_0030574	Biological process	collagen catabolic process
GO_0006879	Biological process	intracellular iron ion homeostasis
GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0097264	Biological process	self proteolysis
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0033619	Biological process	membrane protein proteolysis
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0004252	Molecular function	serine-type endopeptidase activity
GO_0005515	Molecular function	protein binding

Gene name	TMPRSS6
Protein name	Transmembrane protease serine 6 (EC 3.4.21.-) (Matriptase-2) Transmembrane serine protease 6
Synonyms	UNQ354/PRO618
Description	FUNCTION: Membrane-bound serine protease . Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis . .
Accessions	ENST00000442782.7 Q8IU80 B0QYB3 ENST00000429068.1 ENST00000346753.9 [Q8IU80-1] B0QYB6 ENST00000406856.7 [Q8IU80-5] X6REP5 ENST00000381792.6 [Q8IU80-5] ENST00000423761.1 ENST00000676104.1 [Q8IU80-1] ENST00000406725.6 [Q8IU80-1]

TMPRSS6 report